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Research Article

Balanced Codon Usage Optimizes Eukaryotic Translational Efficiency

  • Wenfeng Qian,

    Affiliation: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jian-Rong Yang,

    Affiliations: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

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  • Nathaniel M. Pearson,

    Affiliation: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    Current address: Knome, Cambridge, Massachusetts, United States of America

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  • Calum Maclean,

    Affiliation: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jianzhi Zhang mail

    jianzhi@umich.edu

    Affiliation: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002603

About the Authors

Wenfeng Qian, Jian-Rong Yang, Nathaniel M. Pearson, Calum Maclean, Jianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
Jian-Rong Yang
Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

Corresponding Author

Email: jianzhi@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WQ JZ. Performed the experiments: WQ NMP CM. Analyzed the data: WQ J-RY. Contributed reagents/materials/analysis tools: JZ. Wrote the paper: WQ JZ.