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Research Article

The Atypical Calpains: Evolutionary Analyses and Roles in Caenorhabditis elegans Cellular Degeneration

  • Peter I. Joyce,

    Affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom

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  • Rahul Satija,

    Affiliations: Medical Research Council Mammalian Genetics Unit, Harwell, United Kingdom, Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Maozi Chen,

    Affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom

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  • Patricia E. Kuwabara mail

    p.kuwabara@bristol.ac.uk

    Affiliation: School of Biochemistry, University of Bristol, Bristol, United Kingdom

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002602

About the Authors

Peter I. Joyce, Maozi Chen, Patricia E. Kuwabara
School of Biochemistry, University of Bristol, Bristol, United Kingdom
Rahul Satija
Medical Research Council Mammalian Genetics Unit, Harwell, United Kingdom
Rahul Satija
Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: p.kuwabara@bristol.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PIJ PEK. Performed the experiments: PIJ RS MC PEK. Analyzed the data: PIJ RS MC PEK. Contributed reagents/materials/analysis tools: PIJ RS MC PEK. Wrote the paper: PIJ PEK. Custom profile hidden Markov models for EF hands: RS.