Advertisement
Research Article

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

  • Cristian Pattaro equal contributor,

    equal contributor Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

    Affiliation: Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

    X
  • Anna Köttgen equal contributor,

    equal contributor Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Renal Division, Freiburg University Clinic, Freiburg, Germany

    X
  • Alexander Teumer equal contributor,

    equal contributor Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

    X
  • Maija Garnaas equal contributor,

    equal contributor Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

    Affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Carsten A. Böger equal contributor,

    equal contributor Contributed equally to this work with: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger

    Affiliation: Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany

    X
  • Christian Fuchsberger,

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Matthias Olden,

    Affiliations: Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany, Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany

    X
  • Ming-Huei Chen,

    Affiliations: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Adrienne Tin,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Daniel Taliun,

    Affiliation: Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

    X
  • Man Li,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Xiaoyi Gao,

    Affiliation: Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Mathias Gorski,

    Affiliations: Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    X
  • Qiong Yang,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Claudia Hundertmark,

    Affiliation: Renal Division, Freiburg University Clinic, Freiburg, Germany

    X
  • Meredith C. Foster,

    Affiliation: National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

    X
  • Conall M. O'Seaghdha,

    Affiliations: National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America, Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Nicole Glazer,

    Affiliation: Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Aaron Isaacs,

    Affiliations: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Centre for Medical Systems Biology, Leiden, The Netherlands

    X
  • Ching-Ti Liu,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Albert V. Smith,

    Affiliations: Icelandic Heart Association, Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

    X
  • Jeffrey R. O'Connell,

    Affiliation: Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America

    X
  • Maksim Struchalin,

    Affiliation: Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands

    X
  • Toshiko Tanaka,

    Affiliation: Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America

    X
  • Guo Li,

    Affiliation: University of Washington, Seattle, Washington, United States of America

    X
  • Andrew D. Johnson,

    Affiliation: National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

    X
  • Hinco J. Gierman,

    Affiliation: Department of Developmental Biology, Stanford University, Stanford, California, United States of America

    X
  • Mary Feitosa,

    Affiliation: Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Shih-Jen Hwang,

    Affiliation: National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America

    X
  • Elizabeth J. Atkinson,

    Affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Kurt Lohman,

    Affiliation: Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Marilyn C. Cornelis,

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Åsa Johansson,

    Affiliation: Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    X
  • Anke Tönjes,

    Affiliations: Department of Medicine, University of Leipzig, Leipzig, Germany, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany

    X
  • Abbas Dehghan,

    Affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Vincent Chouraki,

    Affiliation: Inserm UMR744, Institut Pasteur, Lille, France

    X
  • Elizabeth G. Holliday,

    Affiliations: Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle, Australia

    X
  • Rossella Sorice,

    Affiliation: Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy

    X
  • Zoltan Kutalik,

    Affiliations: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

    X
  • Terho Lehtimäki,

    Affiliation: Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere, Finland

    X
  • Tõnu Esko,

    Affiliations: Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia, Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

    X
  • Harshal Deshmukh,

    Affiliation: Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

    X
  • Sheila Ulivi,

    Affiliation: Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy

    X
  • Audrey Y. Chu,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Federico Murgia,

    Affiliation: Institute of Population Genetics – CNR, Sassari, Italy

    X
  • Stella Trompet,

    Affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

    X
  • Medea Imboden,

    Affiliation: Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

    X
  • Barbara Kollerits,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

    X
  • Giorgio Pistis,

    Affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

    X
  • CARDIoGRAM Consortium,
  • ICBP Consortium,
  • CARe Consortium,
  • Wellcome Trust Case Control Consortium 2 (WTCCC2),
  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America

    X
  • Lenore J. Launer,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America

    X
  • Thor Aspelund,

    Affiliations: Icelandic Heart Association, Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

    X
  • Gudny Eiriksdottir,

    Affiliation: Icelandic Heart Association, Research Institute, Kopavogur, Iceland

    X
  • Braxton D. Mitchell,

    Affiliation: Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America

    X
  • Eric Boerwinkle,

    Affiliation: Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America

    X
  • Helena Schmidt,

    Affiliation: Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz, Austria

    X
  • Margherita Cavalieri,

    Affiliation: Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria

    X
  • Madhumathi Rao,

    Affiliation: Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America

    X
  • Frank B. Hu,

    Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Ayse Demirkan,

    Affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Ben A. Oostra,

    Affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Mariza de Andrade,

    Affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Stephen T. Turner,

    Affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Jingzhong Ding,

    Affiliation: Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Jeanette S. Andrews,

    Affiliation: Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Barry I. Freedman,

    Affiliation: Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Wolfgang Koenig,

    Affiliation: Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany

    X
  • Thomas Illig,

    Affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    X
  • Angela Döring,

    Affiliations: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    X
  • H.-Erich Wichmann,

    Affiliations: Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Grosshadern, Neuherberg, Germany

    X
  • Ivana Kolcic,

    Affiliation: Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

    X
  • Tatijana Zemunik,

    Affiliation: Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

    X
  • Mladen Boban,

    Affiliation: Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

    X
  • Cosetta Minelli,

    Affiliation: Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

    X
  • Heather E. Wheeler,

    Affiliations: Department of Genetics, Stanford University, Stanford, California, United States of America, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

    X
  • Wilmar Igl,

    Affiliation: Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    X
  • Ghazal Zaboli,

    Affiliation: Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    X
  • Sarah H. Wild,

    Affiliation: Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

    X
  • Alan F. Wright,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

    X
  • Harry Campbell,

    Affiliation: Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

    X
  • David Ellinghaus,

    Affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

    X
  • Ute Nöthlings,

    Affiliations: Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany, popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany

    X
  • Gunnar Jacobs,

    Affiliations: Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany, popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany

    X
  • Reiner Biffar,

    Affiliation: Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany

    X
  • Karlhans Endlich,

    Affiliation: Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany

    X
  • Florian Ernst,

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

    X
  • Georg Homuth,

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

    X
  • Heyo K. Kroemer,

    Affiliation: Institute of Pharmacology, University of Greifswald, Greifswald, Germany

    X
  • Matthias Nauck,

    Affiliation: Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

    X
  • Sylvia Stracke,

    Affiliation: Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany

    X
  • Uwe Völker,

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

    X
  • Henry Völzke,

    Affiliation: Institute for Community Medicine, University of Greifswald, Greifswald, Germany

    X
  • Peter Kovacs,

    Affiliation: Department of Medicine, University of Leipzig, Leipzig, Germany

    X
  • Michael Stumvoll,

    Affiliations: Department of Medicine, University of Leipzig, Leipzig, Germany, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany

    X
  • Reedik Mägi,

    Affiliations: Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia, Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

    X
  • Albert Hofman,

    Affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Andre G. Uitterlinden,

    Affiliation: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Fernando Rivadeneira,

    Affiliation: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Yurii S. Aulchenko,

    Affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Ozren Polasek,

    Affiliation: Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

    X
  • Nick Hastie,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

    X
  • Veronique Vitart,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

    X
  • Catherine Helmer,

    Affiliations: INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux, France, Université Bordeaux 2 Victor Segalen, Bordeaux, France

    X
  • Jie Jin Wang,

    Affiliations: Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne, Australia

    X
  • Daniela Ruggiero,

    Affiliation: Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy

    X
  • Sven Bergmann,

    Affiliation: Swiss Institute of Bioinformatics, Lausanne, Switzerland

    X
  • Mika Kähönen,

    Affiliation: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

    X
  • Jorma Viikari,

    Affiliation: Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

    X
  • Tiit Nikopensius,

    Affiliation: Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

    X
  • Michael Province,

    Affiliation: Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Shamika Ketkar,

    Affiliation: Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Helen Colhoun,

    Affiliation: Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

    X
  • Alex Doney,

    Affiliation: NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

    X
  • Antonietta Robino,

    Affiliation: Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy

    X
  • Franco Giulianini,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Bernhard K. Krämer,

    Affiliation: University Medical Centre Mannheim, 5th Department of Medicine, Mannheim, Germany

    X
  • Laura Portas,

    Affiliation: Institute of Population Genetics – CNR, Sassari, Italy

    X
  • Ian Ford,

    Affiliation: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom

    X
  • Brendan M. Buckley,

    Affiliation: Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland

    X
  • Martin Adam,

    Affiliation: Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

    X
  • Gian-Andri Thun,

    Affiliation: Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

    X
  • Bernhard Paulweber,

    Affiliation: First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria

    X
  • Margot Haun,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

    X
  • Cinzia Sala,

    Affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

    X
  • Marie Metzger,

    Affiliation: Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif, France

    X
  • Paul Mitchell,

    Affiliation: Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia

    X
  • Marina Ciullo,

    Affiliation: Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy

    X
  • Stuart K. Kim,

    Affiliations: Department of Developmental Biology, Stanford University, Stanford, California, United States of America, Department of Genetics, Stanford University, Stanford, California, United States of America

    X
  • Peter Vollenweider,

    Affiliation: Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

    X
  • Olli Raitakari,

    Affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku, Finland

    X
  • Andres Metspalu,

    Affiliations: Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia, Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

    X
  • Colin Palmer,

    Affiliation: Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

    X
  • Paolo Gasparini,

    Affiliation: Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy

    X
  • Mario Pirastu,

    Affiliation: Institute of Population Genetics – CNR, Sassari, Italy

    X
  • J. Wouter Jukema,

    Affiliations: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands

    X
  • Nicole M. Probst-Hensch,

    Affiliation: Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

    X
  • Florian Kronenberg,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

    X
  • Daniela Toniolo,

    Affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

    X
  • Vilmundur Gudnason,

    Affiliations: Icelandic Heart Association, Research Institute, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

    X
  • Alan R. Shuldiner,

    Affiliations: Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America

    X
  • Josef Coresh,

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

    X
  • Reinhold Schmidt,

    Affiliation: Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria

    X
  • Luigi Ferrucci,

    Affiliation: Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America

    X
  • David S. Siscovick,

    Affiliation: University of Washington, Seattle, Washington, United States of America

    X
  • Cornelia M. van Duijn,

    Affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Ingrid Borecki,

    Affiliation: Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Sharon L. R. Kardia,

    Affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Yongmei Liu,

    Affiliation: Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Gary C. Curhan,

    Affiliation: Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Igor Rudan,

    Affiliation: Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

    X
  • Ulf Gyllensten,

    Affiliation: Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    X
  • James F. Wilson,

    Affiliation: Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom

    X
  • Andre Franke,

    Affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany

    X
  • Peter P. Pramstaller,

    Affiliation: Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy

    X
  • Rainer Rettig,

    Affiliation: Institute of Physiology, University of Greifswald, Greifswald, Germany

    X
  • Inga Prokopenko,

    Affiliation: Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

    X
  • Jacqueline C. M. Witteman,

    Affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Caroline Hayward,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

    X
  • Paul Ridker,

    Affiliations: Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Afshin Parsa,

    Affiliation: Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland, United States of America

    X
  • Murielle Bochud,

    Affiliation: University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland

    X
  • Iris M. Heid,

    Affiliations: Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    X
  • Wolfram Goessling ,

    Affiliations: Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

    These authors were joint senior authors on this work.

    X
  • Daniel I. Chasman ,

    Affiliations: Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    These authors were joint senior authors on this work.

    X
  • W. H. Linda Kao mail,

    foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WHL Kao)

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

    These authors were joint senior authors on this work.

    X
  • Caroline S. Fox mail

    foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WHL Kao)

    Affiliations: National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America, Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    These authors were joint senior authors on this work.

    X
  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002584

About the Authors

Cristian Pattaro, Daniel Taliun, Cosetta Minelli, Peter P. Pramstaller
Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy
Anna Köttgen, Adrienne Tin, Man Li, Josef Coresh, W. H. Linda Kao
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Anna Köttgen, Claudia Hundertmark
Renal Division, Freiburg University Clinic, Freiburg, Germany
Alexander Teumer, Florian Ernst, Georg Homuth, Uwe Völker
Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany
Maija Garnaas
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Carsten A. Böger
Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany
Christian Fuchsberger
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
Matthias Olden
Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
Matthias Olden
Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany
Ming-Huei Chen
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Ming-Huei Chen, Qiong Yang, Ching-Ti Liu
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Xiaoyi Gao, Mary Feitosa, Michael Province, Shamika Ketkar, Ingrid Borecki
Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Mathias Gorski, Iris M. Heid
Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany
Mathias Gorski, Angela Döring, H.-Erich Wichmann, Iris M. Heid
Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Meredith C. Foster, Conall M. O'Seaghdha, Andrew D. Johnson, Shih-Jen Hwang, Caroline S. Fox
National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America
Conall M. O'Seaghdha
Division of Nephrology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Nicole Glazer
Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
Aaron Isaacs, Ayse Demirkan, Ben A. Oostra, Cornelia M. van Duijn
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Aaron Isaacs
Centre for Medical Systems Biology, Leiden, The Netherlands
Albert V. Smith, Thor Aspelund, Gudny Eiriksdottir, Vilmundur Gudnason
Icelandic Heart Association, Research Institute, Kopavogur, Iceland
Albert V. Smith, Thor Aspelund, Vilmundur Gudnason
University of Iceland, Reykjavik, Iceland
Jeffrey R. O'Connell, Braxton D. Mitchell, Alan R. Shuldiner
Department of Medicine, University of Maryland Medical School, Baltimore, Maryland, United States of America
Maksim Struchalin
Department of Epidemiology and Biostatistics and Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands
Toshiko Tanaka, Luigi Ferrucci
Clinical Research Branch, National Institute of Aging, Baltimore, Maryland, United States of America
Guo Li, David S. Siscovick
University of Washington, Seattle, Washington, United States of America
Hinco J. Gierman, Stuart K. Kim
Department of Developmental Biology, Stanford University, Stanford, California, United States of America
Elizabeth J. Atkinson, Mariza de Andrade
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
Kurt Lohman, Yongmei Liu
Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Marilyn C. Cornelis, Frank B. Hu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
Åsa Johansson, Wilmar Igl, Ghazal Zaboli, Ulf Gyllensten
Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Anke Tönjes, Peter Kovacs, Michael Stumvoll
Department of Medicine, University of Leipzig, Leipzig, Germany
Anke Tönjes, Michael Stumvoll
IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
Abbas Dehghan, Albert Hofman, Yurii S. Aulchenko, Jacqueline C. M. Witteman
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Vincent Chouraki
Inserm UMR744, Institut Pasteur, Lille, France
Elizabeth G. Holliday
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Elizabeth G. Holliday
Centre for Information-based Medicine, Hunter Medical Research Institute, Newcastle, Australia
Rossella Sorice, Daniela Ruggiero, Marina Ciullo
Institute of Genetics and Biophysics “Adriano-Buzzati Traverso”–CNR, Napoli, Italy
Zoltan Kutalik
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
Zoltan Kutalik, Sven Bergmann
Swiss Institute of Bioinformatics, Lausanne, Switzerland
Terho Lehtimäki
Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Centre for Laboratory Medicine Tampere Finn-Medi 2, Tampere, Finland
Tõnu Esko, Reedik Mägi, Andres Metspalu
Estonian Genome Center of University of Tartu (EGCUT), Tartu, Estonia
Tõnu Esko, Tiit Nikopensius, Andres Metspalu
Estonian Biocenter and Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Harshal Deshmukh, Helen Colhoun
Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom
Sheila Ulivi
Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy
Audrey Y. Chu, Franco Giulianini, Paul Ridker, Daniel I. Chasman
Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Federico Murgia, Laura Portas, Mario Pirastu
Institute of Population Genetics – CNR, Sassari, Italy
Stella Trompet, J. Wouter Jukema
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Medea Imboden, Martin Adam, Gian-Andri Thun, Nicole M. Probst-Hensch
Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland
Barbara Kollerits, Margot Haun, Florian Kronenberg
Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
Giorgio Pistis, Cinzia Sala, Daniela Toniolo
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
Tamara B. Harris, Lenore J. Launer
Laboratory of Epidemiology, Demography, and Biometry, NIA, Bethesda, Maryland, United States of America
Eric Boerwinkle
Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America
Helena Schmidt
Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Graz, Austria
Margherita Cavalieri, Reinhold Schmidt
Austrian Stroke Prevention Study, University Clinic of Neurology, Department of Special Neurology, Medical University Graz, Graz, Austria
Madhumathi Rao
Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
Stephen T. Turner
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America
Jingzhong Ding
Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Jeanette S. Andrews
Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Barry I. Freedman
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Wolfgang Koenig
Abteilung Innere II, Universitätsklinikum Ulm, Ulm, Germany
Thomas Illig, Angela Döring
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
H.-Erich Wichmann
Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
H.-Erich Wichmann
Klinikum Grosshadern, Neuherberg, Germany
Ivana Kolcic, Tatijana Zemunik, Mladen Boban
Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
Heather E. Wheeler, Stuart K. Kim
Department of Genetics, Stanford University, Stanford, California, United States of America
Heather E. Wheeler
Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
Sarah H. Wild, Harry Campbell, Igor Rudan, James F. Wilson
Center for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
Alan F. Wright, Nick Hastie, Veronique Vitart, Caroline Hayward
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Andre Franke
Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, Germany
Ute Nöthlings, Gunnar Jacobs
popgen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany
Reiner Biffar
Clinic for Prosthodontic Dentistry, Gerostomatology, and Material Science, University of Greifswald, Greifswald, Germany
Karlhans Endlich
Institute of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany
Heyo K. Kroemer
Institute of Pharmacology, University of Greifswald, Greifswald, Germany
Matthias Nauck
Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
Sylvia Stracke
Clinic for Internal Medicine A, University of Greifswald, Greifswald, Germany
Henry Völzke
Institute for Community Medicine, University of Greifswald, Greifswald, Germany
Reedik Mägi, Inga Prokopenko
Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom
Andre G. Uitterlinden, Fernando Rivadeneira
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Ozren Polasek
Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia
Catherine Helmer
INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED, Bordeaux, France
Catherine Helmer
Université Bordeaux 2 Victor Segalen, Bordeaux, France
Jie Jin Wang, Paul Mitchell
Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia
Jie Jin Wang
Centre for Eye Research Australia (CERA), University of Melbourne, Melbourne, Australia
Mika Kähönen
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
Jorma Viikari
Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
Alex Doney
NHS Tayside, Wellcome Trust Centre for Molecular Medicine, Clinical Research Centre, Ninewells Hospital, University of Dundee, Dundee, United Kingdom
Antonietta Robino, Paolo Gasparini
Institute for Maternal and Child Health, IRCCS “Burlo Garofolo,” University of Trieste, Trieste, Italy
Bernhard K. Krämer
University Medical Centre Mannheim, 5th Department of Medicine, Mannheim, Germany
Ian Ford
Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
Brendan M. Buckley
Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland
Bernhard Paulweber
First Department of Internal Medicine, Paracelsus Medical University, Salzburg, Austria
Marie Metzger
Inserm UMRS 1018, CESP Team 10, Université Paris Sud, Villejuif, France
Peter Vollenweider
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Olli Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology, Turku University Hospital, University of Turku, Turku, Finland
Colin Palmer
Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
J. Wouter Jukema
Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands
J. Wouter Jukema
Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands
J. Wouter Jukema
Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands
Alan R. Shuldiner
Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America
Josef Coresh, W. H. Linda Kao
Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America
Sharon L. R. Kardia
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
Gary C. Curhan
Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America
Rainer Rettig
Institute of Physiology, University of Greifswald, Greifswald, Germany
Paul Ridker, Daniel I. Chasman
Harvard Medical School, Boston, Massachusetts, United States of America
Afshin Parsa
Division of Nephrology, University of Maryland Medical School, Baltimore, Maryland, United States of America
Murielle Bochud
University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland
Wolfram Goessling
Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Wolfram Goessling
Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America
Caroline S. Fox
Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Study design: V Gudnason, TB Harris, LJ Launer, G Eiriksdottir, A Parsa, A Köttgen, WHL Kao, R Schmidt, L Ferrucci, DS Siscovick, BA Oostra, CM van Duijn, I Borecki, CS Fox, FB Hu, CA Böger, M Gorski, T Illig, A Döring, HE Wichmann, IM Heid, I Rudan, PP Pramstaller, GC Curhan, U Gyllensten, JF Wilson, SH Wild, AF Wright, H Campbell, A Hofman, AG Uitterlinden, JCM Witteman, R Biffar, K Endlich, R Rettig, S Stracke, H Völzke, P Kovacs, A Tönjes, O Polasek, N Hastie, C Hayward, V Vitart, DI Chasman, P Ridker, C Helmer, A Metspalu, JJ Wang, P Mitchell, M Province, X Gao, M Ciullo, P Vollenweider, M Pirastu, B Paulweber, D Toniolo, T Lehtimäki, O Raitakari, M Kähönen, J Viikari, P Gasparini, H Colhoun, A Doney, C Palmer, H Deshmukh, S Trompet, I Ford, BM Buckley, JW Jukema, NM Probst-Hensch. Study management: V Gudnason, TB Harris, LJ Launer, G Eiriksdottir, A Parsa, WHL Kao, R Schmidt, H Schmidt, M Cavalieri, L Ferrucci, DS Siscovick, A Isaacs, BA Oostra, CM van Duijn, I Borecki, CS Fox, J Ding, Y Liu, MC Cornelis, FB Hu, W Koenig, T Illig, A Döring, HE Wichmann, I Rudan, I Kolcic, T Zemunik, M Boban, C Pattaro, PP Pramstaller, GC Curhan, A Johansson, G Zaboli, U Gyllensten, JF Wilson, SH Wild, U Nöthlings, A Hofman, AG Uitterlinden, JCM Witteman, R Biffar, K Endlich, R Rettig, U Völker, H Völkze, M Stumvoll, A Tönjes, O Polasek, N Hastie, C Hayward, V Vitart, DI Chasman, P Ridker, C Helmer, A Metspalu, JJ Wang, P Mitchell, M Province, X Gao, M Ciullo, M Bochud, P Vollenweider, M Pirastu, B Kollerits, M Haun, B Paulweber, F Kronenberg, D Toniolo, T Lehtimäki, O Raitakari, M Kähönen, J Viikari, P Gasparini, F Giulianini, H Colhoun, A Doney, C Palmer, H Deshmukh, S Trompet, I Ford, BM Buckley, JW Jukema, BK Krämer, NM Probst-Hensch, M Imboden. Subject recruitment: G Eiriksdottir, AR Shuldiner, BD Mitchell, J Coresh, R Schmidt, M Cavalieri, DS Siscovick, BA Oostra, CM van Duijn, TB Harris, T Illig, A Döring, HE Wichmann, I Rudan, I Kolcic, PP Pramstaller, A Johansson, JF Wilson, SH Wild, A Hofman, AG Uitterlinden, JCM Witteman, R Biffar, R Rettig, S Stracke, H Völkze, A Tönjes, O Polasek, C Helmer, P Mitchell, M Ciullo, P Vollenweider, M Pirastu, B Paulweber, D Toniolo, O Raitakari, M Kähönen, J Viikari, S Ulivi, A Robino, P Ridker, H Colhoun, A Doney, C Palmer, I Ford, BM Buckley, JW Jukema, NM Probst-Hensch. Genotyping: AR Shuldiner, BD Mitchell, E Boerwinkle, H Schmidt, A Isaacs, A Demirkan, BA Oostra, CM van Duijn, M de Andrade, EJ Atkinson, ST Turner, SLR Kardia, Y Liu, CA Böger, M Gorski, T Illig, HE Wichmann, IM Heid, JF Wilson, H Campbell, A Franke, AG Uitterlinden, F Rivadeneira, F Ernst, G Homuth, HK Kroemer, M Nauck, U Völker, M Stumvoll, O Polasek, C Hayward, DI Chasman, T Esko, M Haun, F Kronenberg, T Lehtimäki, F Giulianini, S Trompet, JW Jukema. Statistical methods and analysis: T Aspelund, AV Smith, A Parsa, JR O'Connell, A Köttgen, WHL Kao, A Tin, C Hundertmark, M Struchalin, T Tanaka, G Li, A Isaacs, A Demirkan, M Feitosa, CS Fox, MH Chen, MC Foster, SJ Hwang, Q Yang, K Lohman, JS Andrews, Y Liu, MC Cornelis, CA Böger, M Gorski, IM Heid, C Pattaro, D Taliun, C Fuchsberger, C Minelli, A Johansson, W Igl, D Ellinghaus, A Franke, A Dehghan, F Rivadeneira, YS Aulchenko, A Teumer, I Prokopenko, R Mägi, C Hayward, V Vitart, DI Chasman, T Esko, EG Holliday, X Gao, S Ketkar, D Ruggiero, R Sorice, Z Kutalik, S Bergmann, F Murgia, L Portas, B Kollerits, F Kronenberg, G Pistis, S Ulivi, A Robino, AY Chu, H Colhoun, A Doney, C Palmer, H Deshmukh, I Ford, NM Probst-Hensch, M Adam, GA Thun, M Olden, M Li, N Glazer, HJ Gierman, V Chouraki, HE Wheeler, G Jacobs, T Nikopensius, M Metzger. Bioinformatics: AV Smith, JR O'Connell, C Hundertmark, M Struchalin, G Li, MH Chen, Q Yang, K Lohman, JS Andrews, Y Liu, MC Cornelis, CA Böger, M Gorski, IM Heid, C Pattaro, D Taliun, C Fuchsberger, A Johansson, W Igl, D Ellinghaus, A Dehghan, F Rivadeneira, YS Aulchenko, HK Kroemer, A Teumer, I Prokopenko, R Mägi, DI Chasman, T Esko, D Ruggiero, R Sorice, S Bergmann, F Murgia, L Portas, G Pistis, C Sala, T Lehtimäki, O Raitakari, S Ulivi, F Giulianini, S Trompet, I Ford, M Imboden, C-T Liu, AD Johnson, SK Kim. Zebrafish studies: M Garnaas, W Goessling. Interpretation of results: V Gudnason, TB Harris, LJ Launer, AV Smith, A Parsa, A Köttgen, WHL Kao, A Tin, DS Siscovick, G Li, M Rao, A Isaacs, MH Chen, MC Foster, SJ Hwang, Q Yang, J Ding, K Lohman, Y Liu, CA Böger, M Gorski, IM Heid, I Rudan, T Zemunik, M Boban, C Pattaro, D Taliun, A Johansson, W Igl, G Zaboli, U Gyllensten, JF Wilson, SH Wild, R Biffar, K Endlich, HK Kroemer, M Nauck, R Rettig, S Stracke, A Teumer, U Völker, H Völkze, O Polasek, N Hastie, C Hayward, V Vitart, DI Chasman, BI Freedman, T Esko, A Metspalu, EG Holliday, I Borecki, M Province, X Gao, M Ciullo, M Bochud, B Kollerits, M Haun, B Paulweber, F Kronenberg, D Toniolo, G Pistis, C Sala, AY Chu, S Trompet, JW Jukema, M Garnaas, W Goessling, CS Fox. Wrote the manuscript: C Pattaro, A Köttgen, A Teumer, M Garnaas, CA Böger, C Fuchsberger, A Tin, CM O'Seaghdha, A Parsa, M Bochud, IM Heid, W Goessling, DI Chasman, WHL Kao, CS Fox.