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Research Article

Evidence for Positive Selection on a Number of MicroRNA Regulatory Interactions during Recent Human Evolution

  • Jingjing Li equal contributor,

    equal contributor Contributed equally to this work with: Jingjing Li, Yu Liu

    Affiliations: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

    Current address: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Yu Liu equal contributor,

    equal contributor Contributed equally to this work with: Jingjing Li, Yu Liu

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

    X
  • Xiaofeng Xin,

    Affiliations: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

    Current address: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Taehyung Simon Kim,

    Affiliation: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada

    X
  • Eduardo Aguiar Cabeza,

    Affiliation: The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

    X
  • Jie Ren,

    Affiliation: Department of Physics and Centre for Computational Science and Engineering, National University of Singapore, Singapore, Singapore

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  • Rasmus Nielsen,

    Affiliation: Departments of Integrative Biology and Statistics, University of California Berkeley, Berkeley, California, United States of America

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  • Jeffrey L. Wrana mail,

    wrana@lunenfeld.ca (JLW); Zhaolei.Zhang@utoronto.ca (ZZ)

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

    X
  • Zhaolei Zhang mail

    wrana@lunenfeld.ca (JLW); Zhaolei.Zhang@utoronto.ca (ZZ)

    Affiliations: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Published: March 22, 2012
  • DOI: 10.1371/journal.pgen.1002578

About the Authors

Jingjing Li, Xiaofeng Xin, Taehyung Simon Kim, Zhaolei Zhang
Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada
Jingjing Li, Yu Liu, Xiaofeng Xin, Jeffrey L. Wrana, Zhaolei Zhang
Department of Molecular Genetics, University of Toronto, Toronto, Canada
Yu Liu, Eduardo Aguiar Cabeza, Jeffrey L. Wrana
The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Jie Ren
Department of Physics and Centre for Computational Science and Engineering, National University of Singapore, Singapore, Singapore
Rasmus Nielsen
Departments of Integrative Biology and Statistics, University of California Berkeley, Berkeley, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL YL JLW ZZ. Performed the experiments: YL EAC. Analyzed the data: JL YL TSK JR XX. Wrote the paper: JL YL RN JLW ZZ.