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Research Article

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

  • Xiaolin Tu,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    Current address: Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Jianquan Chen,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Joohyun Lim,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Courtney M. Karner,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Seung-Yon Lee,

    Affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Julia Heisig,

    Affiliation: Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany

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  • Cornelia Wiese,

    Affiliation: Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany

    X
  • Kameswaran Surendran,

    Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Raphael Kopan,

    Affiliation: Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Manfred Gessler,

    Affiliation: Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany

    X
  • Fanxin Long mail

    flong@wustl.edu

    Affiliations: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Published: March 22, 2012
  • DOI: 10.1371/journal.pgen.1002577

About the Authors

Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Seung-Yon Lee, Fanxin Long
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
Julia Heisig, Cornelia Wiese, Manfred Gessler
Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany
Kameswaran Surendran, Raphael Kopan, Fanxin Long
Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: flong@wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FL. Performed the experiments: XT JC JL CMK S-YL JH CW. Analyzed the data: XT FL. Contributed reagents/materials/analysis tools: KS RK MG. Wrote the paper: XT FL.