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Research Article

Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal

  • Julie Hunkapiller,

    Affiliation: Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

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  • Yin Shen,

    Affiliation: Ludwig Institute for Cancer Research, School of Medicine, University of California San Diego, San Diego, California, United States of America

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  • Aaron Diaz,

    Affiliation: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Gerard Cagney,

    Affiliation: School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland

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  • David McCleary,

    Affiliation: Ludwig Institute for Cancer Research, School of Medicine, University of California San Diego, San Diego, California, United States of America

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  • Miguel Ramalho-Santos,

    Affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America

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  • Nevan Krogan,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America

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  • Bing Ren,

    Affiliation: Ludwig Institute for Cancer Research, School of Medicine, University of California San Diego, San Diego, California, United States of America

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  • Jun S. Song mail,

    songj@humgen.ucsf.edu (JSS); Jeremy.Reiter@ucsf.edu (JFR)

    Affiliations: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

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  • Jeremy F. Reiter mail

    songj@humgen.ucsf.edu (JSS); Jeremy.Reiter@ucsf.edu (JFR)

    Affiliation: Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002576

About the Authors

Julie Hunkapiller, Jeremy F. Reiter
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
Yin Shen, David McCleary, Bing Ren
Ludwig Institute for Cancer Research, School of Medicine, University of California San Diego, San Diego, California, United States of America
Aaron Diaz, Jun S. Song
Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Gerard Cagney
School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
Miguel Ramalho-Santos
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
Nevan Krogan
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
Jun S. Song
Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JH JFR. Performed the experiments: JH YS DM. Analyzed the data: JH AD GC JSS. Contributed reagents/materials/analysis tools: JFR MR-S JSS BR NK. Wrote the paper: JH JSS JFR.