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Research Article

Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators

  • Jessica L. McLellan equal contributor,

    equal contributor Contributed equally to this work with: Jessica L. McLellan, Nigel J. O'Neil

    Affiliations: Department of Medical Genetics, University of British Columbia, Vancouver, Canada, Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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  • Nigel J. O'Neil equal contributor,

    equal contributor Contributed equally to this work with: Jessica L. McLellan, Nigel J. O'Neil

    Affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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  • Irene Barrett,

    Affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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  • Elizabeth Ferree,

    Affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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  • Derek M. van Pel,

    Affiliations: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada, Department of Biochemistry, University of British Columbia, Vancouver, Canada

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  • Kevin Ushey,

    Affiliation: Department of Statistics, University of British Columbia, Vancouver, Canada

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  • Payal Sipahimalani,

    Affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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  • Jennifer Bryan,

    Affiliations: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada, Department of Statistics, University of British Columbia, Vancouver, Canada

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  • Ann M. Rose,

    Affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Philip Hieter mail

    hieter@msl.ubc.ca

    Affiliations: Department of Medical Genetics, University of British Columbia, Vancouver, Canada, Michael Smith Laboratories, University of British Columbia, Vancouver, Canada, Department of Biochemistry, University of British Columbia, Vancouver, Canada

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002574

About the Authors

Jessica L. McLellan, Ann M. Rose, Philip Hieter
Department of Medical Genetics, University of British Columbia, Vancouver, Canada
Jessica L. McLellan, Nigel J. O'Neil, Irene Barrett, Elizabeth Ferree, Derek M. van Pel, Payal Sipahimalani, Jennifer Bryan, Philip Hieter
Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
Derek M. van Pel, Philip Hieter
Department of Biochemistry, University of British Columbia, Vancouver, Canada
Kevin Ushey, Jennifer Bryan
Department of Statistics, University of British Columbia, Vancouver, Canada

Corresponding Author

Email: hieter@msl.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JLM NJO AMR PH. Performed the experiments: JLM NJO IB DMvP EF PS. Analyzed the data: JLM NJO KU JB PH. Wrote the paper: JLM NJO PH.