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Research Article

Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis

  • Lisa M. Nilsson,

    Affiliations: Department of Molecular Biology, Umeå University, Umeå, Sweden, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden

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  • Tacha Zi Plym Forshell equal contributor,

    equal contributor Contributed equally to this work with: Tacha Zi Plym Forshell, Sara Rimpi

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Sara Rimpi equal contributor,

    equal contributor Contributed equally to this work with: Tacha Zi Plym Forshell, Sara Rimpi

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Christiane Kreutzer,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Walter Pretsch,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany

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  • Georg W. Bornkamm,

    Affiliation: Institute of Clinical Molecular Biology and Tumour Genetics, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany

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  • Jonas A. Nilsson mail

    jonas.a.nilsson@surgery.gu.se

    Affiliations: Department of Molecular Biology, Umeå University, Umeå, Sweden, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002573

About the Authors

Lisa M. Nilsson, Tacha Zi Plym Forshell, Sara Rimpi, Christiane Kreutzer, Jonas A. Nilsson
Department of Molecular Biology, Umeå University, Umeå, Sweden
Lisa M. Nilsson, Jonas A. Nilsson
Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden
Walter Pretsch
Institute of Human Genetics, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany
Georg W. Bornkamm
Institute of Clinical Molecular Biology and Tumour Genetics, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany

Corresponding Author

Email: jonas.a.nilsson@surgery.gu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LMN GWB JAN. Performed the experiments: LMN TZPF SR CK JAN. Analyzed the data: LMN TZPF SR CK GWB JAN. Contributed reagents/materials/analysis tools: WP. Wrote the paper: LMN GWB JAN.