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Research Article

Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

  • Daniel Haag equal contributor,

    equal contributor Contributed equally to this work with: Daniel Haag, Petra Zipper

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Petra Zipper equal contributor,

    equal contributor Contributed equally to this work with: Daniel Haag, Petra Zipper

    Affiliation: Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany

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  • Viola Westrich,

    Affiliation: Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany

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  • Daniela Karra,

    Affiliation: Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany

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  • Karin Pfleger,

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Grischa Toedt,

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Frederik Blond,

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Nicolas Delhomme,

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Meinhard Hahn,

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Julia Reifenberger,

    Affiliation: Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany

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  • Guido Reifenberger,

    Affiliation: Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany

    These authors were joint senior authors on this work.

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  • Peter Lichter mail

    Peter.Lichter@dkfz.de

    Affiliation: Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002572

About the Authors

Daniel Haag, Karin Pfleger, Grischa Toedt, Frederik Blond, Nicolas Delhomme, Meinhard Hahn, Peter Lichter
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Petra Zipper, Viola Westrich, Daniela Karra, Guido Reifenberger
Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany
Julia Reifenberger
Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany

Corresponding Author

Email: Peter.Lichter@dkfz.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DH PZ JR GR PL. Performed the experiments: DH PZ VW DK KP. Analyzed the data: DH PZ GT. Contributed reagents/materials/analysis tools: GT FB ND. Wrote the paper: DH PZ GR PL. Critical revision of the manuscript: DK MH.