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Research Article

Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans

  • Pawel K. Olszewski,

    Affiliations: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden, Minnesota Obesity Center, University of Minnesota, St. Paul, Minnesota, United States of America

    Current address: Department of Biological Sciences, University of Waikato, Hamilton, New Zealand

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  • Jan Rozman,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Molecular Nutritional Medicine, Else Kröner-Fresenius Center and ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany

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  • Josefin A. Jacobsson,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Birgit Rathkolb,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, München, Germany

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  • Siv Strömberg,

    Affiliation: Molecular Cell Biology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Wolfgang Hans,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anica Klockars,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Johan Alsiö,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Ulf Risérus,

    Affiliation: Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

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  • Lore Becker,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, München, Germany

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  • Sabine M. Hölter,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany

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  • Ralf Elvert,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    Current address: Sanofi-Aventis GmbH, Frankfurt am Main, Germany

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  • Nicole Ehrhardt,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    Current address: Department of Medical Genetics, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Valérie Gailus-Durner,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Helmut Fuchs,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Robert Fredriksson,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Eckhard Wolf,

    Affiliation: Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, München, Germany

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  • Thomas Klopstock,

    Affiliation: Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, München, Germany

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  • Wolfgang Wurst,

    Affiliations: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany, Max-Planck-Institute for Psychiatry, München, Germany, Technical University München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik c/o Helmholtz Zentrum München, Neuherberg, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Munich, Germany

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  • Allen S. Levine,

    Affiliation: Minnesota Obesity Center, University of Minnesota, St. Paul, Minnesota, United States of America

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  • Claude Marcus,

    Affiliation: Department for Clinical Science, Intervention, and Technology, Karolinska Institutet, Division of Pediatrics, National Childhood Obesity Centre, Stockholm, Sweden

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  • Martin Hrabě de Angelis,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany

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  • Martin Klingenspor,

    Affiliation: Molecular Nutritional Medicine, Else Kröner-Fresenius Center and ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany

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  • Helgi B. Schiöth ,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

    These authors were joint senior authors on this work.

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  • Manfred W. Kilimann mail

    manfred.kilimann@neuro.uu.se

    Affiliation: Molecular Cell Biology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

    These authors were joint senior authors on this work.

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002568

About the Authors

Pawel K. Olszewski, Josefin A. Jacobsson, Anica Klockars, Johan Alsiö, Robert Fredriksson, Helgi B. Schiöth
Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden
Pawel K. Olszewski, Allen S. Levine
Minnesota Obesity Center, University of Minnesota, St. Paul, Minnesota, United States of America
Jan Rozman, Birgit Rathkolb, Wolfgang Hans, Lore Becker, Sabine M. Hölter, Ralf Elvert, Nicole Ehrhardt, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Jan Rozman, Martin Klingenspor
Molecular Nutritional Medicine, Else Kröner-Fresenius Center and ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany
Birgit Rathkolb, Eckhard Wolf
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, München, Germany
Siv Strömberg, Manfred W. Kilimann
Molecular Cell Biology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden
Ulf Risérus
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Lore Becker, Thomas Klopstock
Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, München, Germany
Sabine M. Hölter, Wolfgang Wurst
Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
Wolfgang Wurst
Max-Planck-Institute for Psychiatry, München, Germany
Wolfgang Wurst
Technical University München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik c/o Helmholtz Zentrum München, Neuherberg, Germany
Wolfgang Wurst
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Munich, Germany
Claude Marcus
Department for Clinical Science, Intervention, and Technology, Karolinska Institutet, Division of Pediatrics, National Childhood Obesity Centre, Stockholm, Sweden
Martin Hrabě de Angelis
Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany

Corresponding Author

Email: manfred.kilimann@neuro.uu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MWK PKO ASL CM UR JR WW TK EW MK VG-D HF MHdA. Performed the experiments: JAJ SS AK JA PKO JR RE NE BR WH LB SMH. Analyzed the data: JAJ RF JR RE MK BR WH LB SMH MWK. Wrote the paper: PKO HBS JR MK MWK.