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Research Article

Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells

  • Daisuke Sakai,

    Affiliations: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan

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  • Jill Dixon,

    Affiliation: Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

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  • Michael J. Dixon,

    Affiliations: Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Paul A. Trainor mail

    pat@stowers.org

    Affiliations: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002566

About the Authors

Daisuke Sakai, Paul A. Trainor
Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
Daisuke Sakai
Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan
Jill Dixon, Michael J. Dixon
Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
Michael J. Dixon
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Paul A. Trainor
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: pat@stowers.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DS PAT. Performed the experiments: DS. Analyzed the data: DS PAT. Contributed reagents/materials/analysis tools: JD MJD. Wrote the paper: DS JD MJD PAT.