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Research Article

Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line

  • Jia Qian Wu equal contributor mail,

    equal contributor Contributed equally to this work with: Jia Qian Wu, Montrell Seay

    Jiaqian2009.wu@gmail.com (JQ Wu); Sherman.Weissman@yale.edu (S Weissman); mpsnyder@stanford.edu (MP Snyder)

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    Current address: Department of Neurosurgery, Center for Stem Cell and Regenerative Medicine, The University of Texas Medical School at Houston, Houston, Texas, United States of America

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  • Montrell Seay equal contributor,

    equal contributor Contributed equally to this work with: Jia Qian Wu, Montrell Seay

    Affiliation: Genetics Department, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Vincent P. Schulz,

    Affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Manoj Hariharan,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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  • David Tuck,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Jin Lian,

    Affiliation: Genetics Department, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Jiang Du,

    Affiliation: Computer Science Department, Yale University, New Haven, Connecticut, United States of America

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  • Minyi Shi,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Zhijia Ye,

    Affiliation: College of Preventive Medicine, Third Military Medical University, Chongqing, China

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  • Mark Gerstein,

    Affiliations: Computer Science Department, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Molecular Biophysics and Biochemistry Department, Yale University, New Haven, Connecticut, United States of America

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  • Michael P. Snyder mail,

    Jiaqian2009.wu@gmail.com (JQ Wu); Sherman.Weissman@yale.edu (S Weissman); mpsnyder@stanford.edu (MP Snyder)

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    These authors are joint senior authors on this work.

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  • Sherman Weissman mail

    Jiaqian2009.wu@gmail.com (JQ Wu); Sherman.Weissman@yale.edu (S Weissman); mpsnyder@stanford.edu (MP Snyder)

    Affiliation: Genetics Department, Yale University School of Medicine, New Haven, Connecticut, United States of America

    These authors are joint senior authors on this work.

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002565

About the Authors

Jia Qian Wu, Manoj Hariharan, Minyi Shi, Michael P. Snyder
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
Montrell Seay, Jin Lian, Sherman Weissman
Genetics Department, Yale University School of Medicine, New Haven, Connecticut, United States of America
Vincent P. Schulz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America
David Tuck
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Jiang Du, Mark Gerstein
Computer Science Department, Yale University, New Haven, Connecticut, United States of America
Zhijia Ye
College of Preventive Medicine, Third Military Medical University, Chongqing, China
Mark Gerstein
Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America
Mark Gerstein
Molecular Biophysics and Biochemistry Department, Yale University, New Haven, Connecticut, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JQ Wu, S Weissman, MP Snyder. Performed the experiments: JQ Wu, M Seay, J Lian, M Shi, Z Ye. Analyzed the data: JQ Wu, VP Schulz, M Hariharan, D Tuck, J Du. Contributed reagents/materials/analysis tools: JQ Wu, M Seay, VP Schulz, M Hariharan, D Tuck, M Gerstein, S Weissman, MP Snyder. Wrote the paper: JQ Wu, S Weissman, MP Snyder.