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Research Article

Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure

  • Emília Ilona Gaál mail,

    emilia.gaal@helsinki.fi

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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  • Perttu Salo equal contributor,

    equal contributor Contributed equally to this work with: Perttu Salo, Kati Kristiansson

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Kati Kristiansson equal contributor,

    equal contributor Contributed equally to this work with: Perttu Salo, Kati Kristiansson

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Karola Rehnström,

    Affiliations: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Johannes Kettunen,

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Antti-Pekka Sarin,

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Mika Niemelä,

    Affiliation: Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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  • Antti Jula,

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Olli T. Raitakari,

    Affiliations: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland

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  • Terho Lehtimäki,

    Affiliation: Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Johan G. Eriksson,

    Affiliations: Diabetes Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland, Vasa Central Hospital, Vasa, Finland, Folkhälsan Research Centre, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland

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  • Elisabeth Widen,

    Affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Murat Günel,

    Affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Mitja Kurki,

    Affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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  • Mikael von und zu Fraunberg,

    Affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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  • Juha E. Jääskeläinen,

    Affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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  • Juha Hernesniemi,

    Affiliation: Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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  • Marjo-Riitta Järvelin,

    Affiliations: Department of Biostatistics and Epidemiology, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland

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  • Anneli Pouta,

    Affiliation: Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland

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  • The International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS),

    Membership of the ICBP-GWAS is available in Text S1.

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  • Christopher Newton-Cheh,

    Affiliations: Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Veikko Salomaa,

    Affiliation: Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Aarno Palotie,

    Affiliations: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

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  • Markus Perola

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, University of Tartu, Estonian Genome Centre, Tartu, Estonia

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002563

About the Authors

Emília Ilona Gaál, Perttu Salo, Kati Kristiansson, Johannes Kettunen, Antti-Pekka Sarin, Antti Jula, Markus Perola
Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
Emília Ilona Gaál, Kati Kristiansson, Karola Rehnström, Johannes Kettunen, Antti-Pekka Sarin, Elisabeth Widen, Aarno Palotie, Markus Perola
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Emília Ilona Gaál, Mika Niemelä, Juha Hernesniemi
Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland
Karola Rehnström, Aarno Palotie
The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Olli T. Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Olli T. Raitakari
Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland
Terho Lehtimäki
Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland
Johan G. Eriksson
Diabetes Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
Johan G. Eriksson
Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland
Johan G. Eriksson
Vasa Central Hospital, Vasa, Finland
Johan G. Eriksson
Folkhälsan Research Centre, Helsinki, Finland
Johan G. Eriksson
Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland
Murat Günel
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, United States of America
Mitja Kurki, Mikael von und zu Fraunberg, Juha E. Jääskeläinen
Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland
Marjo-Riitta Järvelin
Department of Biostatistics and Epidemiology, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom
Marjo-Riitta Järvelin
Institute of Health Sciences, University of Oulu, Oulu, Finland
Marjo-Riitta Järvelin
Biocenter Oulu, University of Oulu, Oulu, Finland
Marjo-Riitta Järvelin, Anneli Pouta
Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland
Christopher Newton-Cheh
Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Christopher Newton-Cheh
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Veikko Salomaa
Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
Aarno Palotie
Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Aarno Palotie
Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland
Markus Perola
University of Tartu, Estonian Genome Centre, Tartu, Estonia

Corresponding Author

Email: emilia.gaal@helsinki.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M Perola, EI Gaál, A Palotie, JE Jääskeläinen, M Niemelä, V Salomaa. Performed the experiments: EI Gaál, P Salo, K Kristiansson, J Kettunen, A-P Sarin. Analyzed the data: EI Gaál, P Salo, K Kristiansson. Contributed reagents/materials/analysis tools: M Kurki, M von und zu Fraunberg, M Günel, M Niemelä, J Hernesniemi, OT Raitakari, T Lehtimäki, E Widen, JG Eriksson, M-R Järvelin, A Pouta, A Jula, V Salomaa, C Newton-Cheh. Wrote the paper: EI Gaál, K Rehnström, P Salo, K Kristiansson, V Salomaa, M Perola, A Palotie.