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Research Article

DNA Damage in Nijmegen Breakage Syndrome Cells Leads to PARP Hyperactivation and Increased Oxidative Stress

  • Harald Krenzlin,

    Affiliation: Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany

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  • Ilja Demuth,

    Affiliations: Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany, The Berlin Aging Study II, Research Group on Geriatrics, Charité – Universitätsmedizin Berlin, Berlin, Germany

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  • Bastian Salewsky,

    Affiliation: Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany

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  • Petra Wessendorf,

    Affiliation: Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany

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  • Kathrin Weidele,

    Affiliation: Molecular Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany

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  • Alexander Bürkle,

    Affiliation: Molecular Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany

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  • Martin Digweed mail

    martin.digweed@charite.de

    Affiliation: Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pgen.1002557

About the Authors

Harald Krenzlin, Ilja Demuth, Bastian Salewsky, Petra Wessendorf, Martin Digweed
Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany
Ilja Demuth
The Berlin Aging Study II, Research Group on Geriatrics, Charité – Universitätsmedizin Berlin, Berlin, Germany
Kathrin Weidele, Alexander Bürkle
Molecular Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany

Corresponding Author

Email: martin.digweed@charite.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MD. Performed the experiments: HK BS PW KW. Analyzed the data: HK MD AB. Contributed reagents/materials/analysis tools: ID. Wrote the paper: HK MD.