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Research Article

Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas

  • Joshua Mark Galanter mail,

    joshua.galanter@ucsf.edu

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • Juan Carlos Fernandez-Lopez,

    Affiliation: Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    X
  • Christopher R. Gignoux,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • Jill Barnholtz-Sloan,

    Affiliation: Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Ceres Fernandez-Rozadilla,

    Affiliation: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    X
  • Marc Via,

    Affiliation: Universitat de Barcelona, Barcelona, Spain

    X
  • Alfredo Hidalgo-Miranda,

    Affiliation: Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    X
  • Alejandra V. Contreras,

    Affiliation: Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    X
  • Laura Uribe Figueroa,

    Affiliation: Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    X
  • Paola Raska,

    Affiliation: Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Gerardo Jimenez-Sanchez,

    Affiliation: Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    X
  • Irma Silva Zolezzi,

    Affiliation: Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    X
  • Maria Torres,

    Affiliation: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    X
  • Clara Ruiz Ponte,

    Affiliation: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    X
  • Yarimar Ruiz,

    Affiliation: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    X
  • Antonio Salas,

    Affiliation: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    X
  • Elizabeth Nguyen,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • Celeste Eng,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • Lisbeth Borjas,

    Affiliation: Universidad del Zulia, Maracaibo, Venezuela

    X
  • William Zabala,

    Affiliations: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, Universidad del Zulia, Maracaibo, Venezuela

    X
  • Guillermo Barreto,

    Affiliation: Universidad del Valle, Santiago de Cali, Colombia

    X
  • Fernando Rondón González,

    Affiliation: Universidad Industrial de Santander, Bucaramanga, Colombia

    X
  • Adriana Ibarra,

    Affiliation: Universidad de Antioquia, Medellín, Colombia

    X
  • Patricia Taboada,

    Affiliations: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, Instituto de Investigaciones Forenses, Sucre, Bolivia

    X
  • Liliana Porras,

    Affiliations: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, Universidad Tecnológica de Pereira, Pereira, Colombia

    X
  • Fabián Moreno,

    Affiliation: Unidad de Genética Forense, Servicio Médico-Legal de Chile, Santiago de Chile, Chile

    X
  • Abigail Bigham,

    Affiliation: University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Gerardo Gutierrez,

    Affiliation: University of Colorado at Boulder, Boulder, Colorado, United States of America

    X
  • Tom Brutsaert,

    Affiliation: Syracuse University, Syracuse, New York, United States of America

    X
  • Fabiola León-Velarde,

    Affiliation: Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Lorna G. Moore,

    Affiliation: Wake Forest University, Winston-Salem, North Carolina, United States of America

    X
  • Enrique Vargas,

    Affiliation: Universidad Mayor de San Andrés, La Paz, Bolivia

    X
  • Miguel Cruz,

    Affiliation: Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico

    X
  • Jorge Escobedo,

    Affiliation: Hospital General Regional 1, IMSS, Mexico City, Mexico

    X
  • José Rodriguez-Santana,

    Affiliation: Centro de Neumología Pediátrica, San Juan, Puerto Rico

    X
  • William Rodriguez-Cintrón,

    Affiliation: VA Caribbean Health System, San Juan, Puerto Rico

    X
  • Rocio Chapela,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico

    X
  • Jean G. Ford,

    Affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Carlos Bustamante,

    Affiliation: Stanford University, Stanford, California, United States of America

    X
  • Daniela Seminara,

    Affiliation: National Cancer Institute, Bethesda, Maryland, United States of America

    X
  • Mark Shriver,

    Affiliation: Penn State University, University Park, Pennsylvania, United States of America

    X
  • Elad Ziv,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • Esteban Gonzalez Burchard,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

    X
  • Robert Haile,

    Affiliation: University of Southern California, Los Angeles, California, United States of America

    X
  • Esteban Parra equal contributor,

    equal contributor Contributed equally to this work with: Esteban Parra, Angel Carracedo

    Affiliation: University of Toronto at Mississauga, Mississauga, Canada

    X
  • Angel Carracedo equal contributor,

    equal contributor Contributed equally to this work with: Esteban Parra, Angel Carracedo

    Affiliation: Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    X
  • for the LACE Consortium
  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002554

About the Authors

Joshua Mark Galanter, Christopher R. Gignoux, Elizabeth Nguyen, Celeste Eng, Elad Ziv, Esteban Gonzalez Burchard
University of California San Francisco, San Francisco, California, United States of America
Juan Carlos Fernandez-Lopez, Alfredo Hidalgo-Miranda, Alejandra V. Contreras, Laura Uribe Figueroa, Gerardo Jimenez-Sanchez, Irma Silva Zolezzi
Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Jill Barnholtz-Sloan, Paola Raska
Case Western Reserve University, Cleveland, Ohio, United States of America
Ceres Fernandez-Rozadilla, Maria Torres, Clara Ruiz Ponte, Yarimar Ruiz, Antonio Salas, William Zabala, Patricia Taboada, Liliana Porras, Angel Carracedo
Fundación Pública Galega de Medicina Xenómica (SERGAS)-CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Marc Via
Universitat de Barcelona, Barcelona, Spain
Lisbeth Borjas, William Zabala
Universidad del Zulia, Maracaibo, Venezuela
Guillermo Barreto
Universidad del Valle, Santiago de Cali, Colombia
Fernando Rondón González
Universidad Industrial de Santander, Bucaramanga, Colombia
Adriana Ibarra
Universidad de Antioquia, Medellín, Colombia
Patricia Taboada
Instituto de Investigaciones Forenses, Sucre, Bolivia
Liliana Porras
Universidad Tecnológica de Pereira, Pereira, Colombia
Fabián Moreno
Unidad de Genética Forense, Servicio Médico-Legal de Chile, Santiago de Chile, Chile
Abigail Bigham
University of Michigan, Ann Arbor, Michigan, United States of America
Gerardo Gutierrez
University of Colorado at Boulder, Boulder, Colorado, United States of America
Tom Brutsaert
Syracuse University, Syracuse, New York, United States of America
Fabiola León-Velarde
Universidad Peruana Cayetano Heredia, Lima, Peru
Lorna G. Moore
Wake Forest University, Winston-Salem, North Carolina, United States of America
Enrique Vargas
Universidad Mayor de San Andrés, La Paz, Bolivia
Miguel Cruz
Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico
Jorge Escobedo
Hospital General Regional 1, IMSS, Mexico City, Mexico
José Rodriguez-Santana
Centro de Neumología Pediátrica, San Juan, Puerto Rico
William Rodriguez-Cintrón
VA Caribbean Health System, San Juan, Puerto Rico
Rocio Chapela
Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico
Jean G. Ford
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Carlos Bustamante
Stanford University, Stanford, California, United States of America
Daniela Seminara
National Cancer Institute, Bethesda, Maryland, United States of America
Mark Shriver
Penn State University, University Park, Pennsylvania, United States of America
Robert Haile
University of Southern California, Los Angeles, California, United States of America
Esteban Parra
University of Toronto at Mississauga, Mississauga, Canada

Corresponding Author

Email: joshua.galanter@ucsf.edu

Competing Interests

CB and EGB are on the Scientific Advisory Board of 23andme's project "Roots into the Future." 23andme is a Mountain View, CA, company that provides direct-to-consumer genetic products. CB is also on the SAB of Ancestry.com, a company in Provo, UT, that provides direct-to-consumer genetic products. Neither company played a part in the research described here or has a financial stake in the results. The remaining authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMG JCF-L CRG DS CB EZ EGB RH EP AC. Performed the experiments: JMG JCF-L CRG CF-R LUF GJ-S MT CRP YR AS EN CE EP AC. Analyzed the data: JMG JCF-L CRG EP AC. Contributed reagents/materials/analysis tools: JCF-L CF-R AH-M AVC LUF PR GJ-S ISZ MT CRP YR AS LB WZ GB FRG AI PT LP FM AB GG TB FL-V LGM EV MC JE JR-S WR-C RC JGF MS EGB EP AC. Wrote the paper: JMG JCF-L CRG JB-S CF-R MV GJ-S EN DS CB EZ EGB RH EP AC.