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Research Article

Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates

  • Ju-Ling Liu,

    Affiliation: Department of Biology, McGill University, Montreal, Canada

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  • David Desjardins,

    Affiliation: Department of Biology, McGill University, Montreal, Canada

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  • Robyn Branicky,

    Affiliation: Department of Biology, McGill University, Montreal, Canada

    Current address: Cell Biology Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Luis B. Agellon,

    Affiliation: School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, Canada

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  • Siegfried Hekimi mail

    Siegfried.Hekimi@McGill.ca

    Affiliation: Department of Biology, McGill University, Montreal, Canada

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002553

About the Authors

Ju-Ling Liu, David Desjardins, Robyn Branicky, Siegfried Hekimi
Department of Biology, McGill University, Montreal, Canada
Luis B. Agellon
School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, Canada

Corresponding Author

Email: Siegfried.Hekimi@McGill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SH DD J-LL RB LBA. Performed the experiments: J-LL DD RB. Analyzed the data: SH J-LL DD RB. Wrote the paper: SH J-LL DD RB LBA.