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Research Article

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

  • Décio L. Eizirik mail,

    deizirik@ulb.ac.be (DLE); mcnop@ulb.ac.be (MC)

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Michael Sammeth,

    Affiliation: Functional Bioinformatics (FBI), Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain

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  • Thomas Bouckenooghe,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Guy Bottu,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Giorgia Sisino,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Mariana Igoillo-Esteve,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Fernanda Ortis,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Izortze Santin,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Maikel L. Colli,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Jenny Barthson,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Luc Bouwens,

    Affiliation: Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel (VUB), Brussels, Belgium

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  • Linda Hughes,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom

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  • Lorna Gregory,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom

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  • Gerton Lunter,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom

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  • Lorella Marselli,

    Affiliation: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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  • Piero Marchetti,

    Affiliation: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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  • Mark I. McCarthy,

    Affiliations: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

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  • Miriam Cnop mail

    deizirik@ulb.ac.be (DLE); mcnop@ulb.ac.be (MC)

    Affiliations: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium, Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002552

About the Authors

Décio L. Eizirik, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo-Esteve, Fernanda Ortis, Izortze Santin, Maikel L. Colli, Jenny Barthson, Miriam Cnop
Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium
Michael Sammeth
Functional Bioinformatics (FBI), Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain
Luc Bouwens
Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel (VUB), Brussels, Belgium
Linda Hughes, Lorna Gregory, Gerton Lunter, Mark I. McCarthy
Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom
Lorella Marselli, Piero Marchetti
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Mark I. McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Mark I. McCarthy
Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom
Miriam Cnop
Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DLE MIM MC. Performed the experiments: TB GS MI-E FO IS MLC JB LB LH LG GL LM PM MC. Analyzed the data: DLE MS GB MIM MC. Contributed reagents/materials/analysis tools: DLE MS LH LG GL LM PM MIM MC. Wrote the paper: DLE MS GB MC.