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Research Article

Exploring the Complexity of the HIV-1 Fitness Landscape

  • Roger D. Kouyos mail,

    sebastian.bonhoeffer@env.ethz.ch (SB); rkouyos@princeton.edu (RDK)

    Affiliations: ETH Zürich, Institute of Integrative Biology, Zürich, Switzerland, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Gabriel E. Leventhal,

    Affiliation: ETH Zürich, Institute of Integrative Biology, Zürich, Switzerland

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  • Trevor Hinkley,

    Affiliation: ETH Zürich, Institute of Integrative Biology, Zürich, Switzerland

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  • Mojgan Haddad,

    Affiliation: Monogram Biosciences, South San Francisco, California, United States of America

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  • Jeannette M. Whitcomb,

    Affiliation: Monogram Biosciences, South San Francisco, California, United States of America

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  • Christos J. Petropoulos,

    Affiliation: Monogram Biosciences, South San Francisco, California, United States of America

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  • Sebastian Bonhoeffer mail

    sebastian.bonhoeffer@env.ethz.ch (SB); rkouyos@princeton.edu (RDK)

    Affiliation: ETH Zürich, Institute of Integrative Biology, Zürich, Switzerland

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002551

About the Authors

Roger D. Kouyos, Gabriel E. Leventhal, Trevor Hinkley, Sebastian Bonhoeffer
ETH Zürich, Institute of Integrative Biology, Zürich, Switzerland
Roger D. Kouyos
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
Mojgan Haddad, Jeannette M. Whitcomb, Christos J. Petropoulos
Monogram Biosciences, South San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RDK GEL TH SB. Performed the experiments: RDK GEL MH JMW CJP TH SB. Analyzed the data: RDK GEL TH SB. Contributed reagents/materials/analysis tools: MH JMW CJP. Wrote the paper: RDK GEL SB.