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Research Article

Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes

  • Xiaoyun Wu,

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Zhen Shi,

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mingxue Cui,

    Affiliations: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado, United States of America

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  • Min Han,

    Affiliations: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado, United States of America

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  • Gary Ruvkun mail

    ruvkun@molbio.mgh.harvard.edu

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002542

About the Authors

Xiaoyun Wu, Zhen Shi, Gary Ruvkun
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Xiaoyun Wu, Zhen Shi, Gary Ruvkun
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Mingxue Cui, Min Han
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America
Mingxue Cui, Min Han
Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado, United States of America

Corresponding Author

Email: ruvkun@molbio.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XW ZS MC MH GR. Performed the experiments: XW ZS MC. Analyzed the data: XW ZS MC MH GR. Contributed reagents/materials/analysis tools: XW ZS MC. Wrote the paper: XW GR.