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Research Article

A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1

  • Yuji Urabe,

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Departments of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Chizu Tanikawa,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Atsushi Takahashi,

    Affiliation: Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Yukinori Okada,

    Affiliation: Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Takashi Morizono,

    Affiliation: Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Tatsuhiko Tsunoda,

    Affiliation: Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Naoyuki Kamatani,

    Affiliation: Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Kenjiro Kohri,

    Affiliation: Department of Nephro-Urology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan

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  • Kazuaki Chayama,

    Affiliations: Departments of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Michiaki Kubo,

    Affiliation: Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan

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  • Yusuke Nakamura,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Koichi Matsuda mail

    koichima@ims.u-tokyo.ac.jp

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pgen.1002541

About the Authors

Yuji Urabe, Chizu Tanikawa, Yusuke Nakamura, Koichi Matsuda
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Yuji Urabe, Kazuaki Chayama
Departments of Medical and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Atsushi Takahashi, Yukinori Okada, Takashi Morizono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kazuaki Chayama, Michiaki Kubo
Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
Kenjiro Kohri
Department of Nephro-Urology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan

Corresponding Author

Email: koichima@ims.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YU KK KC YN KM. Performed the experiments: YU CT MK. Analyzed the data: AT YO TM TT NK. Contributed reagents/materials/analysis tools: YN KM MK. Wrote the paper: YU YN KM.