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Research Article

A Downstream CpG Island Controls Transcript Initiation and Elongation and the Methylation State of the Imprinted Airn Macro ncRNA Promoter

  • Martha V. Koerner,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Current address: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Florian M. Pauler,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Quanah J. Hudson,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Federica Santoro,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Anna Sawicka,

    Affiliation: Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria

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  • Philipp M. Guenzl,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Stefan H. Stricker,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Current address: UCL Cancer Institute, University College London, London, United Kingdom

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  • Yvonne M. Schichl,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Current address: Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria

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  • Paulina A. Latos,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Current address: The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom

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  • Ruth M. Klement,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Katarzyna E. Warczok,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Jacek Wojciechowski,

    Affiliation: IMP/IMBA Transgenic Service, Research Institute of Molecular Pathology, Vienna, Austria

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  • Christian Seiser,

    Affiliation: Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria

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  • Robert Kralovics,

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Denise P. Barlow mail

    dbarlow@cemm.oeaw.ac.at

    Affiliation: CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pgen.1002540

About the Authors

Martha V. Koerner, Florian M. Pauler, Quanah J. Hudson, Federica Santoro, Philipp M. Guenzl, Stefan H. Stricker, Yvonne M. Schichl, Paulina A. Latos, Ruth M. Klement, Katarzyna E. Warczok, Robert Kralovics, Denise P. Barlow
CeMM–Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
Anna Sawicka, Christian Seiser
Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria
Jacek Wojciechowski
IMP/IMBA Transgenic Service, Research Institute of Molecular Pathology, Vienna, Austria

Corresponding Author

Email: dbarlow@cemm.oeaw.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MVK FMP SHS YMS RMK CS RK DPB. Performed the experiments: MVK FMP FS QJH SHS YMS PAL RMK KEW JW PMG AS. Analyzed the data: MVK FMP FS YMS RMK QJH DPB. Wrote the paper: MVK FMP DPB.