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Research Article

LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients

  • MyLinh T. Duong,

    Affiliations: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America

    X
  • Said Akli,

    Affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Caimiao Wei,

    Affiliation: Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Hannah F. Wingate,

    Affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Wenbin Liu,

    Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Yiling Lu,

    Affiliation: Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Min Yi,

    Affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Gordon B. Mills,

    Affiliations: Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Kelly K. Hunt mail,

    kkeyomar@mdanderson.org (KK); khunt@mdanderson.org (KKH)

    Affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Khandan Keyomarsi mail

    kkeyomar@mdanderson.org (KK); khunt@mdanderson.org (KKH)

    Affiliations: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002538

About the Authors

MyLinh T. Duong, Said Akli, Khandan Keyomarsi
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
MyLinh T. Duong, Gordon B. Mills, Khandan Keyomarsi
Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America
Caimiao Wei
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Hannah F. Wingate, Min Yi, Kelly K. Hunt
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Wenbin Liu
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Yiling Lu, Gordon B. Mills
Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GBM KKH KK. Performed the experiments: MTD SA HFW YL. Analyzed the data: CW MY WL. Wrote the paper: MTD KK. Performed the statistical and bioinformatic analysis for this manuscript: CW MY WL.