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Research Article

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

  • Song Liu equal contributor,

    equal contributor Contributed equally to this work with: Song Liu, Tomoyo Sawada

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Tomoyo Sawada equal contributor,

    equal contributor Contributed equally to this work with: Song Liu, Tomoyo Sawada

    Affiliations: Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan

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  • Seongsoo Lee,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Wendou Yu,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • George Silverio,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Philomena Alapatt,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ivan Millan,

    Affiliation: Neuroscience Program, Stanford University School of Medicine, Stanford, California, United States of America

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  • Alice Shen,

    Affiliation: College of Arts and Sciences, Washington University, St. Louis, Missouri, United States of America

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  • William Saxton,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Tomoko Kanao,

    Affiliation: Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan

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  • Ryosuke Takahashi,

    Affiliations: Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan

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  • Nobutaka Hattori,

    Affiliations: CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan, Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan

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  • Yuzuru Imai mail,

    yzimai@juntendo.ac.jp (YI); bingwei@stanford.edu (BL)

    Affiliation: Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan

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  • Bingwei Lu mail

    yzimai@juntendo.ac.jp (YI); bingwei@stanford.edu (BL)

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pgen.1002537

About the Authors

Song Liu, Seongsoo Lee, Wendou Yu, George Silverio, Philomena Alapatt, Bingwei Lu
Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
Tomoyo Sawada, Ryosuke Takahashi
Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Tomoyo Sawada, Ryosuke Takahashi, Nobutaka Hattori
CREST (Core Research for Evolutionary Science and Technology), Japan Science and Technology Agency, Saitama, Japan
Ivan Millan
Neuroscience Program, Stanford University School of Medicine, Stanford, California, United States of America
Alice Shen
College of Arts and Sciences, Washington University, St. Louis, Missouri, United States of America
William Saxton
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
Tomoko Kanao
Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan
Nobutaka Hattori
Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan
Yuzuru Imai
Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL BL YI TS RT. Performed the experiments: SL TS SL WY GS PA IM AS TK YI. Analyzed the data: SL TS WS RT YI BL. Contributed reagents/materials/analysis tools: WS NH. Wrote the paper: BL SL YI.