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Research Article

Genome-Wide Association Study in East Asians Identifies Novel Susceptibility Loci for Breast Cancer

  • Jirong Long equal contributor,

    equal contributor Contributed equally to this work with: Jirong Long, Qiuyin Cai

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Qiuyin Cai equal contributor,

    equal contributor Contributed equally to this work with: Jirong Long, Qiuyin Cai

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Hyuna Sung,

    Affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

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  • Jiajun Shi,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ben Zhang,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ji-Yeob Choi,

    Affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

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  • Wanqing Wen,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ryan J. Delahanty,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Wei Lu,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Yu-Tang Gao,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Hongbing Shen,

    Affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China

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  • Sue K. Park,

    Affiliations: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Kexin Chen,

    Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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  • Chen-Yang Shen,

    Affiliations: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, College of Public Health, China Medical University, Taichung, Taiwan

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  • Zefang Ren,

    Affiliation: School of Public Health, Sun Yat-sen University, Guangzhou, China

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  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California and Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

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  • Keitaro Matsuo,

    Affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

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  • Mi Kyung Kim,

    Affiliations: Cancer Epidemiology Division, Breast Cancer Center, National Cancer Center, Goyang, Korea, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea

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  • Ui Soon Khoo,

    Affiliation: Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China

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  • Motoki Iwasaki,

    Affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

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  • Ying Zheng,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Yong-Bing Xiang,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Kai Gu,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Nathaniel Rothman,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Wenjing Wang,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Zhibin Hu,

    Affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China

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  • Yao Liu,

    Affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China

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  • Keun-Young Yoo,

    Affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea

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  • Dong-Young Noh,

    Affiliations: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

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  • Bok-Ghee Han,

    Affiliation: Center for Genome Science, Korea National Institute of Health, Seoul, Korea

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  • Min Hyuk Lee,

    Affiliation: Department of Surgery, Soonchunhyang University Hospital, Bucheon, Korea

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  • Hong Zheng,

    Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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  • Lina Zhang,

    Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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  • Pei-Ei Wu,

    Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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  • Ya-Lan Shieh,

    Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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  • Sum Yin Chan,

    Affiliation: Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China

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  • Shenming Wang,

    Affiliation: First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

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  • Xiaoming Xie,

    Affiliation: Cancer Center, Sun Yat-sen University, Guangzhou, China

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  • Sung-Won Kim,

    Affiliations: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

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  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California and Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Hidemi Ito,

    Affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

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  • Yoshio Kasuga,

    Affiliation: Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan

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  • Sei-Hyun Ahn,

    Affiliations: Cancer Epidemiology Division, Breast Cancer Center, National Cancer Center, Goyang, Korea, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea

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  • Han Sung Kang,

    Affiliations: Cancer Epidemiology Division, Breast Cancer Center, National Cancer Center, Goyang, Korea, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea

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  • Kelvin Y. K. Chan,

    Affiliations: Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China, Department of Obstetrics and Gynecology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China

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  • Hiroji Iwata,

    Affiliation: Department of Breast Oncology, Aichi Cancer Center Central Hospital, Nagoya, Japan

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  • Shoichiro Tsugane,

    Affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

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  • Chun Li,

    Affiliation: Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Xiao-Ou Shu,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Dae-Hee Kang,

    Affiliations: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Wei Zheng mail

    wei.zheng@vanderbilt.edu

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.pgen.1002532

About the Authors

Jirong Long, Qiuyin Cai, Jiajun Shi, Ben Zhang, Wanqing Wen, Ryan J. Delahanty, Xiao-Ou Shu, Wei Zheng
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Hyuna Sung, Ji-Yeob Choi, Sue K. Park, Dae-Hee Kang
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
Wei Lu, Ying Zheng, Kai Gu, Wenjing Wang
Shanghai Center for Disease Control and Prevention, Shanghai, China
Yu-Tang Gao, Yong-Bing Xiang
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Hongbing Shen, Zhibin Hu, Yao Liu
Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China
Sue K. Park, Keun-Young Yoo, Dae-Hee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
Sue K. Park, Dong-Young Noh, Sung-Won Kim, Dae-Hee Kang
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Kexin Chen, Hong Zheng, Lina Zhang
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Chen-Yang Shen, Pei-Ei Wu, Ya-Lan Shieh
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Chen-Yang Shen
College of Public Health, China Medical University, Taichung, Taiwan
Zefang Ren
School of Public Health, Sun Yat-sen University, Guangzhou, China
Christopher A. Haiman, Brian E. Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California and Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Keitaro Matsuo, Hidemi Ito
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Mi Kyung Kim, Sei-Hyun Ahn, Han Sung Kang
Cancer Epidemiology Division, Breast Cancer Center, National Cancer Center, Goyang, Korea
Mi Kyung Kim, Sei-Hyun Ahn, Han Sung Kang
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea
Ui Soon Khoo, Kelvin Y. K. Chan
Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
Motoki Iwasaki, Shoichiro Tsugane
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
Nathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
Dong-Young Noh, Sung-Won Kim
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
Bok-Ghee Han
Center for Genome Science, Korea National Institute of Health, Seoul, Korea
Min Hyuk Lee
Department of Surgery, Soonchunhyang University Hospital, Bucheon, Korea
Sum Yin Chan
Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China
Shenming Wang
First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Xiaoming Xie
Cancer Center, Sun Yat-sen University, Guangzhou, China
Loic Le Marchand
Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America
Yoshio Kasuga
Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan
Kelvin Y. K. Chan
Department of Obstetrics and Gynecology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
Hiroji Iwata
Department of Breast Oncology, Aichi Cancer Center Central Hospital, Nagoya, Japan
Chun Li
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Corresponding Author

Email: wei.zheng@vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the overall study: W Zheng. Performed genotyping experiments: J Shi, H Zheng. Wrote the manuscript: J Long, W Zheng, Q Cai, X-O Shu. Significantly contributed to writing the manuscript: C Li, W Wen, RJ Delahanty. Coordinated genotyping assays: Q Cai, J Long. Managed genotyping data: J Long, B Zhang. Performed statistical analyses: J Long, C Li, W Wen. Directed lab operations: Q Cai. Directed the GWAS in Korea: D-H Kang. Assisted the GWAS in Korea: H Sung, J-Y Choi. Contributed to data and biological collection of the original studies: H Shen, J-Y Choi, W Lu, Y-T Gao, H Shen, SK Park, K Chen, C-Y Shen, Z Ren, CA Haiman, K Matsuo, MK Kim, US Khoo, M Iwasaki, Y Zheng, Y-B Xiang, K Gu, N Rothman, W Wang, Z Hu, Y Liu, K-Y Yoo, D-Y Noh, B-G Han, MH Lee, H Zheng, L Zhang, P-E Wu, Y-L Shieh, SY Chan, S Wang, X Xie, S-W Kim, BE Henderson, L Le Marchand, H Ito, Y Kasuga, S-H Ahn, HS Kang, KYK Chan, H Iwata, S Tsugane, D-H Kang, X-O Shu, W Zheng.