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Research Article

Mixed Effects Modeling of Proliferation Rates in Cell-Based Models: Consequence for Pharmacogenomics and Cancer

  • Hae Kyung Im mail,

    haky@uchicago.edu

    Affiliation: Department of Health Studies, University of Chicago, Chicago, Illinois, United States of America

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  • Eric R. Gamazon,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Amy L. Stark,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • R. Stephanie Huang,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Nancy J. Cox,

    Affiliations: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • M. Eileen Dolan

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Published: February 09, 2012
  • DOI: 10.1371/journal.pgen.1002525

About the Authors

Hae Kyung Im
Department of Health Studies, University of Chicago, Chicago, Illinois, United States of America
Eric R. Gamazon, R. Stephanie Huang, Nancy J. Cox, M. Eileen Dolan
Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
Amy L. Stark, Nancy J. Cox
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: haky@uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HKI. Performed the experiments: HKI ERG. Analyzed the data: HKI ERG. Contributed reagents/materials/analysis tools: MED NJC ERG RSH ALS. Wrote the paper: HKI. Edited and approved the manuscript: HKI ERG MED RSH NJC ALS.