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Research Article

Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway

  • Kenichiro Taniguchi,

    Affiliation: Department of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, United States of America

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  • Anoush E. Anderson,

    Affiliation: Department of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, United States of America

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  • Ann E. Sutherland,

    Affiliation: Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United States of America

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  • David Wotton mail

    dw2p@virginia.edu

    Affiliation: Department of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, United States of America

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.pgen.1002524

About the Authors

Kenichiro Taniguchi, Anoush E. Anderson, David Wotton
Department of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia, United States of America
Ann E. Sutherland
Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United States of America

Corresponding Author

Email: dw2p@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KT DW. Performed the experiments: KT AEA. Analyzed the data: KT AEA AES DW. Wrote the paper: KT AES DW.