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Research Article

Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

  • Maureen J. Koslowski,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Zora Teltschik,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Julia Beisner,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Elke Schaeffeler,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Guoxing Wang,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Irmgard Kübler,

    Affiliation: Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Michael Gersemann,

    Affiliations: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Rachel Cooney,

    Affiliation: Medical Science Division, John Radcliffe Hospital, Oxford, United Kingdom

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  • Derek Jewell,

    Affiliation: Medical Science Division, John Radcliffe Hospital, Oxford, United Kingdom

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  • Walter Reinisch,

    Affiliation: Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria

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  • Séverine Vermeire,

    Affiliation: Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium

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  • Paul Rutgeerts,

    Affiliation: Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium

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  • Matthias Schwab,

    Affiliations: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany, Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital, Tübingen, Germany

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  • Eduard F. Stange,

    Affiliation: Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Jan Wehkamp mail

    jan.wehkamp@ikp-stuttgart.de

    Affiliations: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.pgen.1002523

About the Authors

Maureen J. Koslowski, Zora Teltschik, Julia Beisner, Elke Schaeffeler, Guoxing Wang, Michael Gersemann, Matthias Schwab, Jan Wehkamp
Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
Irmgard Kübler, Michael Gersemann, Eduard F. Stange, Jan Wehkamp
Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany
Rachel Cooney, Derek Jewell
Medical Science Division, John Radcliffe Hospital, Oxford, United Kingdom
Walter Reinisch
Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
Séverine Vermeire, Paul Rutgeerts
Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Matthias Schwab
Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital, Tübingen, Germany

Corresponding Author

Email: jan.wehkamp@ikp-stuttgart.de

Competing Interests

Patent application (No: PCT/EP2009/009176, Publication Number: WO2010/072389): Method for determining the predisposition for Crohn's Disease.

Author Contributions

Conceived and designed the experiments: MJK JW. Performed the experiments: MJK ZT MG GW IK JB. Analyzed the data: MJK ZT JB JW. Contributed reagents/materials/analysis tools: ES MG IK RC DJ WR SV PR MS EFS. Wrote the paper: MJK EFS JW. Recruiting and phenotyping of patients and controls in the association study: RC DJ WR SV PR. Obtained plasmids and performed pretests: GW. Involved in discussion of methods and data: JB ES MS.