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Research Article

Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

  • Jahan-Yar Parsa,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Shaliny Ramachandran,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Ahmad Zaheen,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Rajeev M. Nepal,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Anat Kapelnikov,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Antoaneta Belcheva,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Maribel Berru,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Diana Ronai,

    Affiliation: Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

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  • Alberto Martin mail

    alberto.martin@utoronto.ca

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Published: February 09, 2012
  • DOI: 10.1371/journal.pgen.1002518

About the Authors

Jahan-Yar Parsa, Shaliny Ramachandran, Ahmad Zaheen, Rajeev M. Nepal, Anat Kapelnikov, Antoaneta Belcheva, Maribel Berru, Alberto Martin
Department of Immunology, University of Toronto, Toronto, Canada
Diana Ronai
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

Corresponding Author

Email: alberto.martin@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JY-P DR AM. Performed the experiments: JY-P SR AZ RMN AB MB AK. Analyzed the data: JY-P SR AZ RMN AB MB DR AM AK. Wrote the paper: JY-P AM.