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Research Article

Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants

  • Kailiang Sun,

    Affiliations: Department of Developmental Biology, Sloan-Kettering Institute, New York, New York, United States of America, Neuroscience Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America

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  • Jakub Orzechowski Westholm,

    Affiliation: Department of Developmental Biology, Sloan-Kettering Institute, New York, New York, United States of America

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  • Kazuya Tsurudome,

    Affiliation: Department of Physiology, McGill University, Montreal, Canada

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  • Joshua W. Hagen,

    Affiliation: Department of Developmental Biology, Sloan-Kettering Institute, New York, New York, United States of America

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  • Yubing Lu,

    Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Minoree Kohwi,

    Affiliation: Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Doron Betel,

    Affiliations: Department of Medicine, Weill Cornell Medical School, New York, New York, United States of America, Institute of Computational Biomedicine, Weill Cornell Medical School, New York, New York, United States of America

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  • Fen-Biao Gao,

    Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • A. Pejmun Haghighi,

    Affiliation: Department of Physiology, McGill University, Montreal, Canada

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  • Chris Q. Doe,

    Affiliation: Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America

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  • Eric C. Lai mail

    laie@mskcc.org

    Affiliation: Department of Developmental Biology, Sloan-Kettering Institute, New York, New York, United States of America

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  • Published: February 09, 2012
  • DOI: 10.1371/journal.pgen.1002515

About the Authors

Kailiang Sun, Jakub Orzechowski Westholm, Joshua W. Hagen, Eric C. Lai
Department of Developmental Biology, Sloan-Kettering Institute, New York, New York, United States of America
Kailiang Sun
Neuroscience Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America
Kazuya Tsurudome, A. Pejmun Haghighi
Department of Physiology, McGill University, Montreal, Canada
Yubing Lu, Fen-Biao Gao
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Minoree Kohwi, Chris Q. Doe
Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
Doron Betel
Department of Medicine, Weill Cornell Medical School, New York, New York, United States of America
Doron Betel
Institute of Computational Biomedicine, Weill Cornell Medical School, New York, New York, United States of America

Corresponding Author

Email: laie@mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KS JOW DB F-BG APH CQD ECL. Performed the experiments: KS JOW KT JWH YL MK DB. Analyzed the data: KS JOW KT JWH YL MK DB F-BG APH CQD ECL. Wrote the paper: KS JOW ECL.