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Research Article

Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease

  • Haoyan Chen,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Genki Hayashi,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Olivia Y. Lai,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Alexander Dilthey,

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

    X
  • Peter J. Kuebler,

    Affiliation: Division of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Tami V. Wong,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Maureen P. Martin,

    Affiliation: Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Marcelo A. Fernandez Vina,

    Affiliation: Department of Pathology, Stanford University, Palo Alto, California, United States of America

    X
  • Gil McVean,

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

    X
  • Matthias Wabl,

    Affiliation: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Kieron S. Leslie,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Toby Maurer,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Jeffrey N. Martin,

    Affiliation: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Steven G. Deeks,

    Affiliation: HIV/AIDS Program, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Mary Carrington,

    Affiliation: Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Anne M. Bowcock,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, United States of America

    X
  • Douglas F. Nixon,

    Affiliation: Division of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Wilson Liao mail

    liaowi@derm.ucsf.edu

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Published: February 16, 2012
  • DOI: 10.1371/journal.pgen.1002514
  • Featured in PLOS Collections

About the Authors

Haoyan Chen, Genki Hayashi, Olivia Y. Lai, Tami V. Wong, Kieron S. Leslie, Toby Maurer, Wilson Liao
Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America
Alexander Dilthey, Gil McVean
Department of Statistics, University of Oxford, Oxford, United Kingdom
Peter J. Kuebler, Douglas F. Nixon
Division of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America
Maureen P. Martin, Mary Carrington
Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, Maryland, United States of America
Marcelo A. Fernandez Vina
Department of Pathology, Stanford University, Palo Alto, California, United States of America
Matthias Wabl
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
Jeffrey N. Martin
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Steven G. Deeks
HIV/AIDS Program, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Anne M. Bowcock
Division of Human Genetics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Corresponding Author

Email: liaowi@derm.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HC MW KSL TM DFN WL. Performed the experiments: MAFV AMB WL MC JNM SGD OYL GH TVW MPM. Analyzed the data: HC GH WL. Contributed reagents/materials/analysis tools: AD PJK GM. Wrote the paper: HC WL.