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Research Article

Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution

  • Jinho Kim,

    Affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea

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  • Inhae Kim,

    Affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea

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  • Jae-Seong Yang,

    Affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea

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  • Young-Eun Shin,

    Affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea

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  • Jihye Hwang,

    Affiliation: Division of ITCE, Pohang University of Science and Technology, Pohang, Korea

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  • Solip Park,

    Affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea

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  • Yoon Sup Choi,

    Affiliation: Cancer Research Institute, Seoul National University, Seoul, Korea

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  • Sanguk Kim mail

    sukim@postech.ac.kr

    Affiliations: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea, Division of ITCE, Pohang University of Science and Technology, Pohang, Korea

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  • Published: February 09, 2012
  • DOI: 10.1371/journal.pgen.1002510

About the Authors

Jinho Kim, Inhae Kim, Young-Eun Shin, Sanguk Kim
Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea
Jae-Seong Yang, Solip Park, Sanguk Kim
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea
Jihye Hwang, Sanguk Kim
Division of ITCE, Pohang University of Science and Technology, Pohang, Korea
Yoon Sup Choi
Cancer Research Institute, Seoul National University, Seoul, Korea

Corresponding Author

Email: sukim@postech.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JK SK. Performed the experiments: JK IK J-SY SP. Analyzed the data: JK IK J-SY Y-ES JH SP YSC SK. Wrote the paper: JK IK SK.