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Research Article

Raf1 Is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification

  • Alessia Buscaino,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Sharon A. White,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Douglas R. Houston,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Erwan Lejeune,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Femke Simmer,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

    Current address: Department of Molecular Biology, NCMLS, Radboud University Nijmegen, Nijmegen, The Netherlands

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  • Flavia de Lima Alves,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Piyush T. Diyora,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Takeshi Urano,

    Affiliation: Department of Biochemistry, Shimane University Faculty of Medicine, Izumo, Japan

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  • Elizabeth H. Bayne,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

    Current address: Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Juri Rappsilber,

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Robin C. Allshire mail

    robin.allshire@ed.ac.uk

    Affiliation: Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Published: February 02, 2012
  • DOI: 10.1371/journal.pgen.1002499

About the Authors

Alessia Buscaino, Sharon A. White, Douglas R. Houston, Erwan Lejeune, Femke Simmer, Flavia de Lima Alves, Piyush T. Diyora, Elizabeth H. Bayne, Juri Rappsilber, Robin C. Allshire
Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom
Takeshi Urano
Department of Biochemistry, Shimane University Faculty of Medicine, Izumo, Japan

Corresponding Author

Email: robin.allshire@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB SAW FS RCA. Performed the experiments: AB SAW DRH EL FS FdLA PTD EHB. Analyzed the data: AB SAW DRH EL FS FdLA JR RCA. Contributed reagents/materials/analysis tools: TU DRH JR. Wrote the paper: AB RCA.