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Research Article

A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

  • Rehan Qayyum mail,

    rqayyum@jhmi.edu

    Affiliation: GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

    X
  • Beverly M. Snively,

    Affiliation: Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Elad Ziv,

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Michael A. Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Yongmei Liu,

    Affiliation: Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Weihong Tang,

    Affiliation: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America

    X
  • Lisa R. Yanek,

    Affiliation: GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

    X
  • Leslie Lange,

    Affiliation: Department of Genetics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Michele K. Evans,

    Affiliation: Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Santhi Ganesh,

    Affiliation: Division of Cardiology, University of Michigan Health System, Ann Arbor, Michigan, United States of America

    X
  • Melissa A. Austin,

    Affiliations: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Guillaume Lettre,

    Affiliation: Montreal Heart Institute, Montreal, Canada

    X
  • Diane M. Becker,

    Affiliation: GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

    X
  • Alan B. Zonderman,

    Affiliation: Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Andrew B. Singleton,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Tamara B. Harris,

    Affiliation: Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Emile R. Mohler,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Benjamin A. Logsdon,

    Affiliation: Program in Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Charles Kooperberg,

    Affiliation: Program in Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Aaron R. Folsom,

    Affiliation: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America

    X
  • James G. Wilson,

    Affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Lewis C. Becker equal contributor,

    equal contributor Contributed equally to this work with: Lewis C. Becker, Alexander P. Reiner

    Affiliation: GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

    X
  • Alexander P. Reiner equal contributor

    equal contributor Contributed equally to this work with: Lewis C. Becker, Alexander P. Reiner

    Affiliation: Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002491

About the Authors

Rehan Qayyum, Lisa R. Yanek, Diane M. Becker, Lewis C. Becker
GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
Beverly M. Snively
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Elad Ziv
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Michael A. Nalls, Andrew B. Singleton
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
Yongmei Liu
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Weihong Tang, Aaron R. Folsom
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America
Leslie Lange
Department of Genetics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Michele K. Evans
Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Santhi Ganesh
Division of Cardiology, University of Michigan Health System, Ann Arbor, Michigan, United States of America
Melissa A. Austin, Alexander P. Reiner
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Melissa A. Austin
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Guillaume Lettre
Montreal Heart Institute, Montreal, Canada
Alan B. Zonderman
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Tamara B. Harris
Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Emile R. Mohler
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Benjamin A. Logsdon, Charles Kooperberg
Program in Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
James G. Wilson
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Corresponding Author

Email: rqayyum@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RQ BMS MAN GL MAA DMB SG ABZ ABS JGW LCB APR ERM. Performed the experiments: EZ YL MAN WT LL MKE TBH MAA DMB ABZ ABS TBH JGW LCB APR BAL ARF CK. Analyzed the data: RQ BMS LRY DMB TBH JGW APR BAL CK. Contributed reagents/materials/analysis tools: BMS EZ MAN YL WT LRY MKE SG MAA GL DMB ABZ ABS TBH JGW LCB APR ERM BAL ARF CK. Wrote the paper: RQ DMB LCB APR. Interpreted the results and revised the paper: RQ BMS EZ MAN YL WT LRY LL SG MAA GL DMB JGW LCB ARF APR.