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Research Article

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity

  • Erin K. Butler equal contributor,

    equal contributor Contributed equally to this work with: Erin K. Butler, Aaron Voigt

    Affiliations: Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany, Department of Neurodegeneration and Restorative Research, Center Molecular Physiology of the Brain (CMPB), Georg-August University Göttingen, Göttingen, Germany, Göttingen Graduate School for Neurosciences and Molecular Biology (GGNB), Göttingen, Germany

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  • Aaron Voigt equal contributor,

    equal contributor Contributed equally to this work with: Erin K. Butler, Aaron Voigt

    Affiliation: Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany

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  • A. Kathrin Lutz,

    Affiliation: Neurobiochemistry, Adolf-Butenandt-Institute, Ludwig Maximilians University, Munich, Germany

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  • Jane P. Toegel,

    Affiliation: Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany

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  • Ellen Gerhardt,

    Affiliation: Department of Neurodegeneration and Restorative Research, Center Molecular Physiology of the Brain (CMPB), Georg-August University Göttingen, Göttingen, Germany

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  • Peter Karsten,

    Affiliation: Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany

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  • Björn Falkenburger,

    Affiliation: Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany

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  • Andrea Reinartz,

    Affiliation: Department of Pathology, University Medical Center, RWTH Aachen, Aachen, Germany

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  • Konstanze F. Winklhofer,

    Affiliations: Neurobiochemistry, Adolf-Butenandt-Institute, Ludwig Maximilians University, Munich, Germany, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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  • Jörg B. Schulz mail

    jschulz@ukaachen.de

    Affiliations: Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany, Jülich-Aachen Research Alliance (JARA) Brain, Jülich/Aachen, Germany

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  • Published: February 02, 2012
  • DOI: 10.1371/journal.pgen.1002488

About the Authors

Erin K. Butler, Aaron Voigt, Jane P. Toegel, Peter Karsten, Björn Falkenburger, Jörg B. Schulz
Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany
Erin K. Butler, Ellen Gerhardt
Department of Neurodegeneration and Restorative Research, Center Molecular Physiology of the Brain (CMPB), Georg-August University Göttingen, Göttingen, Germany
Erin K. Butler
Göttingen Graduate School for Neurosciences and Molecular Biology (GGNB), Göttingen, Germany
A. Kathrin Lutz, Konstanze F. Winklhofer
Neurobiochemistry, Adolf-Butenandt-Institute, Ludwig Maximilians University, Munich, Germany
Andrea Reinartz
Department of Pathology, University Medical Center, RWTH Aachen, Aachen, Germany
Konstanze F. Winklhofer
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Jörg B. Schulz
Jülich-Aachen Research Alliance (JARA) Brain, Jülich/Aachen, Germany

Corresponding Author

Email: jschulz@ukaachen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EKB AV KFW JBS. Performed the experiments: EKB EG AKL JPT PK BF AR. Analyzed the data: EKB AV KFW JBS. Wrote the paper: EKB AV JBS.