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Research Article

Genomic Restructuring in the Tasmanian Devil Facial Tumour: Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour

  • Janine E. Deakin equal contributor mail,

    equal contributor Contributed equally to this work with: Janine E. Deakin, Hannah S. Bender

    janine.deakin@anu.edu.au

    Affiliation: Research School of Biology, The Australian National University, Canberra, Australia

    X
  • Hannah S. Bender equal contributor,

    equal contributor Contributed equally to this work with: Janine E. Deakin, Hannah S. Bender

    Affiliation: Research School of Biology, The Australian National University, Canberra, Australia

    X
  • Anne-Maree Pearse,

    Affiliation: Department of Primary Industries, Parks, Water, and Environment, Prospect, Australia

    X
  • Willem Rens,

    Affiliation: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

    X
  • Patricia C. M. O'Brien,

    Affiliation: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

    X
  • Malcolm A. Ferguson-Smith,

    Affiliation: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

    X
  • Yuanyuan Cheng,

    Affiliation: Faculty of Veterinary Science, University of Sydney, Sydney, Australia

    X
  • Katrina Morris,

    Affiliation: Faculty of Veterinary Science, University of Sydney, Sydney, Australia

    X
  • Robyn Taylor,

    Affiliation: Department of Primary Industries, Parks, Water, and Environment, Prospect, Australia

    X
  • Andrew Stuart,

    Affiliation: Genome Resource Center, Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America

    X
  • Katherine Belov,

    Affiliation: Faculty of Veterinary Science, University of Sydney, Sydney, Australia

    X
  • Chris T. Amemiya,

    Affiliation: Genome Resource Center, Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America

    X
  • Elizabeth P. Murchison,

    Affiliation: Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    X
  • Anthony T. Papenfuss,

    Affiliations: Bioinformatics Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Australia, Department of Mathematics and Statistics, University of Melbourne, Melbourne, Australia

    X
  • Jennifer A. Marshall Graves

    Affiliation: Research School of Biology, The Australian National University, Canberra, Australia

    X
  • Published: February 16, 2012
  • DOI: 10.1371/journal.pgen.1002483

About the Authors

Janine E. Deakin, Hannah S. Bender, Jennifer A. Marshall Graves
Research School of Biology, The Australian National University, Canberra, Australia
Anne-Maree Pearse, Robyn Taylor
Department of Primary Industries, Parks, Water, and Environment, Prospect, Australia
Willem Rens, Patricia C. M. O'Brien, Malcolm A. Ferguson-Smith
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Yuanyuan Cheng, Katrina Morris, Katherine Belov
Faculty of Veterinary Science, University of Sydney, Sydney, Australia
Andrew Stuart, Chris T. Amemiya
Genome Resource Center, Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America
Elizabeth P. Murchison
Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Anthony T. Papenfuss
Bioinformatics Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Australia
Anthony T. Papenfuss
Department of Mathematics and Statistics, University of Melbourne, Melbourne, Australia

Corresponding Author

Email: janine.deakin@anu.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JED A-MP JAMG. Performed the experiments: JED HSB A-MP WR PCMO MAF-S YC KM RT AS KB CTA. Analyzed the data: JED HSB. Contributed reagents/materials/analysis tools: EPM ATP. Wrote the paper: JED HSB JAMG.