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Research Article

A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

  • Marianne Chabod,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Christophe Pedros,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Lucille Lamouroux,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Céline Colacios,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Isabelle Bernard,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Dominique Lagrange,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Daniela Balz-Hara,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Jean-Francois Mosnier,

    Affiliation: Université de Nantes, Faculté de Médecine, EA Biométadys, Nantes, France

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  • Christian Laboisse,

    Affiliation: Université de Nantes, Faculté de Médecine, EA Biométadys, Nantes, France

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  • Nathalie Vergnolle,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Olivier Andreoletti,

    Affiliation: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France

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  • Marie-Paule Roth,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Roland Liblau,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Gilbert J. Fournié,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Abdelhadi Saoudi mail,

    abdelhadi.saoudi@inserm.fr

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Anne S. Dejean

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Published: January 19, 2012
  • DOI: 10.1371/journal.pgen.1002461

About the Authors

Marianne Chabod, Christophe Pedros, Lucille Lamouroux, Céline Colacios, Isabelle Bernard, Dominique Lagrange, Daniela Balz-Hara, Nathalie Vergnolle, Marie-Paule Roth, Roland Liblau, Gilbert J. Fournié, Abdelhadi Saoudi, Anne S. Dejean
UMR Inserm, U1043, Toulouse, France
Marianne Chabod, Christophe Pedros, Lucille Lamouroux, Céline Colacios, Isabelle Bernard, Dominique Lagrange, Daniela Balz-Hara, Nathalie Vergnolle, Marie-Paule Roth, Roland Liblau, Gilbert J. Fournié, Abdelhadi Saoudi, Anne S. Dejean
UMR CNRS, U5282, Toulouse, France
Marianne Chabod, Christophe Pedros, Lucille Lamouroux, Céline Colacios, Isabelle Bernard, Dominique Lagrange, Daniela Balz-Hara, Nathalie Vergnolle, Marie-Paule Roth, Roland Liblau, Gilbert J. Fournié, Abdelhadi Saoudi, Anne S. Dejean
Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France
Jean-Francois Mosnier, Christian Laboisse
Université de Nantes, Faculté de Médecine, EA Biométadys, Nantes, France
Olivier Andreoletti
UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France

Corresponding Author

Email: abdelhadi.saoudi@inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC CP ASD AS RL GJF MP-R. Performed the experiments: CP IB DL CC GJF LL NV DB-H OA MC. Analyzed the data: MC CP ASD AS MP-R GJF OA CL J-FM NV. Wrote the paper: AS GJF ASD. Supervised overall project: AS GJF ASD.