Advertisement
Research Article

Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance

  • Ilya M. Alexandrov equal contributor,

    equal contributor Contributed equally to this work with: Ilya M. Alexandrov, Maria Ivshina

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Maria Ivshina equal contributor,

    equal contributor Contributed equally to this work with: Ilya M. Alexandrov, Maria Ivshina

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Dae Young Jung,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Randall Friedline,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Hwi Jin Ko,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Mei Xu,

    Affiliation: Research Computing, Information Service Department, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Bryan O'Sullivan-Murphy,

    Affiliations: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Rita Bortell,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Yen-Tsung Huang,

    Affiliation: Departments of Epidemiology and Biostatistics, Harvard University, Boston, Massachusetts, United States of America

    X
  • Fumihiko Urano,

    Affiliations: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Jason K. Kim,

    Affiliations: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Joel D. Richter mail

    joel.richter@umassmed.edu

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Published: January 12, 2012
  • DOI: 10.1371/journal.pgen.1002457

About the Authors

Ilya M. Alexandrov, Maria Ivshina, Dae Young Jung, Randall Friedline, Hwi Jin Ko, Bryan O'Sullivan-Murphy, Rita Bortell, Fumihiko Urano, Jason K. Kim, Joel D. Richter
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Mei Xu
Research Computing, Information Service Department, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Bryan O'Sullivan-Murphy, Fumihiko Urano
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Yen-Tsung Huang
Departments of Epidemiology and Biostatistics, Harvard University, Boston, Massachusetts, United States of America
Jason K. Kim
Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: joel.richter@umassmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IMA MI FU JKK JDR. Performed the experiments: IMA MI DYJ RF HJK BO-M RB. Analyzed the data: IMA MI RF FU MX Y-TH JKK JDR. Contributed reagents/materials/analysis tools: MX. Wrote the paper: IMA MI JDR.