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Research Article

Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks

  • Hisato Kobayashi,

    Affiliation: Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan

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  • Takayuki Sakurai,

    Affiliation: Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan

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  • Misaki Imai,

    Affiliation: Genome Research Center, NODAI Research Institute, Tokyo University of Agriculture, Tokyo, Japan

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  • Nozomi Takahashi,

    Affiliation: Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan

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  • Atsushi Fukuda,

    Affiliation: Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan

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  • Obata Yayoi,

    Affiliation: Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan

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  • Shun Sato,

    Affiliation: Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Kazuhiko Nakabayashi,

    Affiliation: Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Kenichiro Hata,

    Affiliation: Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Yusuke Sotomaru,

    Affiliation: Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan

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  • Yutaka Suzuki,

    Affiliation: Department of Medical Genome Sciences, Graduate School of Frontier, The University of Tokyo, Kashiwa, Japan

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  • Tomohiro Kono mail

    tomohiro@nodai.ac.jp

    Affiliations: Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan, Genome Research Center, NODAI Research Institute, Tokyo University of Agriculture, Tokyo, Japan

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  • Published: January 05, 2012
  • DOI: 10.1371/journal.pgen.1002440

About the Authors

Hisato Kobayashi, Takayuki Sakurai, Nozomi Takahashi, Atsushi Fukuda, Obata Yayoi, Tomohiro Kono
Department of BioScience, Tokyo University of Agriculture, Tokyo, Japan
Misaki Imai, Tomohiro Kono
Genome Research Center, NODAI Research Institute, Tokyo University of Agriculture, Tokyo, Japan
Shun Sato, Kazuhiko Nakabayashi, Kenichiro Hata
Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan
Yusuke Sotomaru
Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan
Yutaka Suzuki
Department of Medical Genome Sciences, Graduate School of Frontier, The University of Tokyo, Kashiwa, Japan

Corresponding Author

Email: tomohiro@nodai.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: H Kobayashi, Y Suzuki, T Kono. Performed the experiments: H Kobayashi, T Sakurai. Analyzed the data: H Kobayashi, M Imai, Y Suzuki. Contributed reagents/materials/analysis tools: H Kobayashi, T Sakurai, M Imai, N Takahashi, A Fukuda, O Yayoi, S Sato, K Nakabayashi, K Hata, Y Sotomaru, Y Suzuki. Wrote the paper: H Kobayashi, T Kono.