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Research Article

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

  • Yingleong Chan equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Oddgeir L. Holmen equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliations: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway, St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway

    X
  • Andrew Dauber equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliations: Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Lars Vatten,

    Affiliation: Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway

    X
  • Aki S. Havulinna,

    Affiliation: National Institute for Health and Welfare, Helsinki, Finland

    X
  • Frank Skorpen,

    Affiliation: Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway

    X
  • Kirsti Kvaløy,

    Affiliation: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway

    X
  • Kaisa Silander,

    Affiliations: National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

    X
  • Thutrang T. Nguyen,

    Affiliation: Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Cristen Willer,

    Affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Michael Boehnke,

    Affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Markus Perola,

    Affiliations: National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Estonian Genome Project, University of Tartu, Tartu, Estonia

    X
  • Aarno Palotie,

    Affiliations: Broad Institute, Cambridge, Massachusetts, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

    X
  • Veikko Salomaa,

    Affiliation: National Institute for Health and Welfare, Helsinki, Finland

    X
  • Kristian Hveem,

    Affiliation: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway

    X
  • Timothy M. Frayling equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliation: Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    X
  • Joel N. Hirschhorn equal contributor mail,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    joelh@broadinstitute.org(JNH); michael.weedon@pms.ac.uk (MNW)

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Michael N. Weedon equal contributor mail

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    joelh@broadinstitute.org(JNH); michael.weedon@pms.ac.uk (MNW)

    Affiliation: Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    X
  • Published: December 29, 2011
  • DOI: 10.1371/journal.pgen.1002439

About the Authors

Yingleong Chan, Joel N. Hirschhorn
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Yingleong Chan, Andrew Dauber, Aarno Palotie, Joel N. Hirschhorn
Broad Institute, Cambridge, Massachusetts, United States of America
Yingleong Chan, Andrew Dauber, Thutrang T. Nguyen, Joel N. Hirschhorn
Children's Hospital Boston, Boston, Massachusetts, United States of America
Oddgeir L. Holmen, Kirsti Kvaløy, Kristian Hveem
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway
Oddgeir L. Holmen
St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway
Lars Vatten
Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
Aki S. Havulinna, Kaisa Silander, Markus Perola, Veikko Salomaa
National Institute for Health and Welfare, Helsinki, Finland
Frank Skorpen
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway
Kaisa Silander, Markus Perola, Aarno Palotie
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Cristen Willer, Michael Boehnke
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Markus Perola
Estonian Genome Project, University of Tartu, Tartu, Estonia
Aarno Palotie
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Aarno Palotie
Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland
Timothy M. Frayling, Michael N. Weedon
Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YC OLH AD TMF JNH MNW. Performed the experiments: YC OLH AD LV ASH FS KK KS TTN CW MB MP AP VS KH TMF JNH MNW. Analyzed the data: YC OLH AD TMF JNH MNW. Contributed reagents/materials/analysis tools: LV ASH FS KK KS TTN CW MB MP AP VS KH. Wrote the paper: YC OLH AD TMF JNH MNW. Made revisions to the paper: YC OLH AD FS MB TMF JNH MNW.