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Research Article

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression

  • Jingyuan Fu mail,

    fjingyuan@gmail.com (JF); lude@ludesign.nl (LF)

    Affiliations: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Marcel G. M. Wolfs,

    Affiliation: Department of Pathology and Medical Biology, Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Patrick Deelen,

    Affiliation: Hanze University Groningen, Groningen, The Netherlands

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  • Harm-Jan Westra,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Rudolf S. N. Fehrmann,

    Affiliations: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Gerard J. te Meerman,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Wim A. Buurman,

    Affiliation: Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute (NUTRIM), Maastricht University, Maastricht, The Netherlands

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  • Sander S. M. Rensen,

    Affiliation: Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute (NUTRIM), Maastricht University, Maastricht, The Netherlands

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  • Harry J. M. Groen,

    Affiliation: Department of Pulmonology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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  • Rinse K. Weersma,

    Affiliation: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Leonard H. van den Berg,

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Jan Veldink,

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Roel A. Ophoff,

    Affiliation: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Harold Snieder,

    Affiliation: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • David van Heel,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Ritsert C. Jansen,

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Marten H. Hofker,

    Affiliation: Department of Pathology and Medical Biology, Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Cisca Wijmenga,

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Lude Franke mail

    fjingyuan@gmail.com (JF); lude@ludesign.nl (LF)

    Affiliation: Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Published: January 19, 2012
  • DOI: 10.1371/journal.pgen.1002431

About the Authors

Jingyuan Fu, Harm-Jan Westra, Rudolf S. N. Fehrmann, Gerard J. te Meerman, Cisca Wijmenga, Lude Franke
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Jingyuan Fu, Harold Snieder
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Marcel G. M. Wolfs, Marten H. Hofker
Department of Pathology and Medical Biology, Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Patrick Deelen
Hanze University Groningen, Groningen, The Netherlands
Rudolf S. N. Fehrmann
Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Wim A. Buurman, Sander S. M. Rensen
Department of Surgery, University Hospital Maastricht and Nutrition and Toxicology Research Institute (NUTRIM), Maastricht University, Maastricht, The Netherlands
Harry J. M. Groen
Department of Pulmonology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Rinse K. Weersma
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Leonard H. van den Berg, Jan Veldink
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Roel A. Ophoff
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
David van Heel
Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Ritsert C. Jansen
Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JF LF CW MHH. Wrote the paper: JF LF. Collected tissues: WAB SSMR HJMG RKW LHvdB JV DvH. Conducted genotyping: CW RAO. Conducted expression profiling: MGMW CW MHH. Bioinformatics and statistical analyses: JF PD H-JW LF. Bioinformatics support: RCJ. PCA-based normalization: RSNF GJtM LF. Helped to improve the manuscript: HS RCJ CW.