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Research Article

A Densely Interconnected Genome-Wide Network of MicroRNAs and Oncogenic Pathways Revealed Using Gene Expression Signatures

  • Chia Huey Ooi,

    Affiliation: Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore

    Current address: Translational Research Sciences, Bioinformatics and Exploratory Data Analysis (BEDA), Roche Diagnostics GmbH, Penzberg, Germany

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  • Hue Kian Oh,

    Affiliations: Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore, Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore

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  • Hannah Zhu'Ai Wang,

    Affiliation: Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore

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  • Angie Lay Keng Tan,

    Affiliations: Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore, Duke-NUS Genome Biology Facility, Duke-NUS Graduate Medical School, Singapore, Singapore

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  • Jeanie Wu,

    Affiliations: Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore, Duke-NUS Genome Biology Facility, Duke-NUS Graduate Medical School, Singapore, Singapore

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  • Minghui Lee,

    Affiliations: Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore, Duke-NUS Genome Biology Facility, Duke-NUS Graduate Medical School, Singapore, Singapore

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  • Sun Young Rha,

    Affiliation: Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea

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  • Hyun Cheol Chung,

    Affiliation: Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea

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  • David Marc Virshup,

    Affiliation: Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore

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  • Patrick Tan mail

    gmstanp@duke-nus.edu.sg

    Affiliations: Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore, Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore, Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Life Sciences, Singapore, Singapore, Genome Institute of Singapore, Singapore, Singapore

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.pgen.1002415

About the Authors

Chia Huey Ooi, Hue Kian Oh, Hannah Zhu'Ai Wang, Angie Lay Keng Tan, David Marc Virshup, Patrick Tan
Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore
Hue Kian Oh, Jeanie Wu, Minghui Lee, Patrick Tan
Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore
Angie Lay Keng Tan, Jeanie Wu, Minghui Lee
Duke-NUS Genome Biology Facility, Duke-NUS Graduate Medical School, Singapore, Singapore
Sun Young Rha, Hyun Cheol Chung
Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea
Patrick Tan
Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Life Sciences, Singapore, Singapore
Patrick Tan
Genome Institute of Singapore, Singapore, Singapore

Corresponding Author

Email: gmstanp@duke-nus.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHO HKO DMV PT. Performed the experiments: CHO HKO HZW ALKT JW ML. Analyzed the data: CHO HKO. Contributed reagents/materials/analysis tools: SYR HCC. Wrote the paper: CHO PT.