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Research Article

A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap

  • Paula S. Ramos mail,

    ramosp@musc.edu

    Affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Lindsey A. Criswell,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

    X
  • Kathy L. Moser,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Mary E. Comeau,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

    X
  • Adrienne H. Williams,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

    X
  • Nicholas M. Pajewski,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

    X
  • Sharon A. Chung,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

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  • Robert R. Graham,

    Affiliation: Immunology Biomarkers Group, Genentech, South San Francisco, California, United States of America

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  • Raphael Zidovetzki,

    Affiliation: Department of Cell Biology and Neuroscience, University of California Riverside, Riverside, California, United States of America

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  • Jennifer A. Kelly,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Kenneth M. Kaufman,

    Affiliation: Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Chaim O. Jacob,

    Affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Timothy J. Vyse,

    Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom

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  • Betty P. Tsao,

    Affiliation: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Robert P. Kimberly,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Patrick M. Gaffney,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Marta E. Alarcón-Riquelme,

    Affiliations: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Centro de Genómica y Investigaciones Oncológicas, Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain

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  • John B. Harley,

    Affiliation: Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Carl D. Langefeld,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • for The International Consortium on the Genetics of Systemic Erythematosus (SLEGEN)

    Membership of SLEGEN is provided in the Acknowledgments.

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.pgen.1002406

About the Authors

Paula S. Ramos
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
Lindsey A. Criswell, Sharon A. Chung
Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America
Kathy L. Moser, Jennifer A. Kelly, Patrick M. Gaffney, Marta E. Alarcón-Riquelme
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
Mary E. Comeau, Adrienne H. Williams, Nicholas M. Pajewski, Carl D. Langefeld
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America
Robert R. Graham
Immunology Biomarkers Group, Genentech, South San Francisco, California, United States of America
Raphael Zidovetzki
Department of Cell Biology and Neuroscience, University of California Riverside, Riverside, California, United States of America
Kenneth M. Kaufman, John B. Harley
Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Chaim O. Jacob
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Timothy J. Vyse
Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom
Betty P. Tsao
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Robert P. Kimberly
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Marta E. Alarcón-Riquelme
Centro de Genómica y Investigaciones Oncológicas, Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain

Corresponding Author

Email: ramosp@musc.edu

Competing Interests

RRG is an employee of Genentech.

Author Contributions

Conceived and designed the experiments: PSR NMP CDL. Performed the experiments: PSR MEC AHW NMP. Analyzed the data: PSR NMP. Contributed reagents/materials/analysis tools: LAC KLM NMP SAC RRG RZ JAK KMK COJ TJV BPT RPK PMG MEA-R JBH CDL. Wrote the paper: PSR LAC NMP SAC CDL.