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Research Article

Genome-Wide Meta-Analysis of Five Asian Cohorts Identifies PDGFRA as a Susceptibility Locus for Corneal Astigmatism

  • Qiao Fan,

    Affiliation: School of Public Health, National University of Singapore, Singapore, Singapore

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  • Xin Zhou,

    Affiliation: School of Public Health, National University of Singapore, Singapore, Singapore

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  • Chiea-Chuen Khor,

    Affiliations: Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore, Department of Pediatrics, National University of Singapore, Singapore, Singapore

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  • Ching-Yu Cheng,

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

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  • Liang-Kee Goh,

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Duke–National University of Singapore Graduate Medical School, Singapore, Singapore, Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore

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  • Xueling Sim,

    Affiliation: Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore

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  • Wan-Ting Tay,

    Affiliation: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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  • Yi-Ju Li,

    Affiliations: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Rick Twee-Hee Ong,

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore

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  • Chen Suo,

    Affiliation: Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore

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  • Belinda Cornes,

    Affiliation: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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  • Mohammad Kamran Ikram,

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Duke–National University of Singapore Graduate Medical School, Singapore, Singapore, Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Kee-Seng Chia,

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore

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  • Mark Seielstad,

    Affiliation: Institute for Human Genetics and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Jianjun Liu,

    Affiliation: Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore, Singapore

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  • Eranga Vithana,

    Affiliations: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

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  • Terri L. Young,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • E.-Shyong Tai,

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Department of Medicine, National University of Singapore, Singapore, Singapore

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  • Tien-Yin Wong equal contributor,

    equal contributor Contributed equally to this work with: Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia

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  • Tin Aung equal contributor,

    equal contributor Contributed equally to this work with: Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw

    Affiliations: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

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  • Yik-Ying Teo equal contributor mail,

    equal contributor Contributed equally to this work with: Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw

    statyy@nus.edu.sg

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore, Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore

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  • Seang-Mei Saw equal contributor

    equal contributor Contributed equally to this work with: Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw

    Affiliations: School of Public Health, National University of Singapore, Singapore, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore

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  • Published: December 01, 2011
  • DOI: 10.1371/journal.pgen.1002402

About the Authors

Qiao Fan, Xin Zhou, Ching-Yu Cheng, Liang-Kee Goh, Rick Twee-Hee Ong, Mohammad Kamran Ikram, Kee-Seng Chia, E.-Shyong Tai, Tien-Yin Wong, Yik-Ying Teo, Seang-Mei Saw
School of Public Health, National University of Singapore, Singapore, Singapore
Chiea-Chuen Khor, Jianjun Liu, Yik-Ying Teo
Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore, Singapore
Chiea-Chuen Khor, Ching-Yu Cheng, Wan-Ting Tay, Belinda Cornes, Mohammad Kamran Ikram, Eranga Vithana, Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
Chiea-Chuen Khor, Xueling Sim, Chen Suo, Kee-Seng Chia
Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
Chiea-Chuen Khor
Department of Pediatrics, National University of Singapore, Singapore, Singapore
Ching-Yu Cheng, Eranga Vithana, Tien-Yin Wong, Tin Aung, Seang-Mei Saw
Department of Ophthalmology, National University of Singapore, Singapore, Singapore
Liang-Kee Goh, Mohammad Kamran Ikram
Duke–National University of Singapore Graduate Medical School, Singapore, Singapore
Liang-Kee Goh
Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore
Yi-Ju Li, Terri L. Young
Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America
Yi-Ju Li
Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America
Rick Twee-Hee Ong, Kee-Seng Chia, Yik-Ying Teo, Seang-Mei Saw
NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore
Mohammad Kamran Ikram
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
Mark Seielstad
Institute for Human Genetics and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
E.-Shyong Tai
Department of Medicine, National University of Singapore, Singapore, Singapore
Tien-Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Yik-Ying Teo
Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore

Corresponding Author

Email: statyy@nus.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: S-MS Y-YT TA T-YW E-ST TLY EV JL MS K-SC. Performed the experiments: QF XZ C-CK C-YC L-KG XS W-TT Y-JL RT-HO CS BC MKI. Analyzed the data: QF XZ C-CK C-YC. Contributed reagents/materials/analysis tools: Y-YT LK-G QF XS RT-HO. Wrote the paper: QF Y-YT S-MS.