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Research Article

The FGFR4-G388R Polymorphism Promotes Mitochondrial STAT3 Serine Phosphorylation to Facilitate Pituitary Growth Hormone Cell Tumorigenesis

  • Toru Tateno,

    Affiliations: Ontario Cancer Institute, University Health Network, Toronto, Canada, The Endocrine Oncology Site Group, Princess Margaret Hospital, Toronto, Canada, Department of Medicine, University of Toronto, Toronto, Canada

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  • Sylvia L. Asa,

    Affiliations: Ontario Cancer Institute, University Health Network, Toronto, Canada, The Endocrine Oncology Site Group, Princess Margaret Hospital, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

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  • Lei Zheng,

    Affiliations: Ontario Cancer Institute, University Health Network, Toronto, Canada, The Endocrine Oncology Site Group, Princess Margaret Hospital, Toronto, Canada, Department of Medicine, University of Toronto, Toronto, Canada

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  • Thomas Mayr,

    Affiliation: Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany

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  • Axel Ullrich,

    Affiliation: Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany

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  • Shereen Ezzat mail

    shereen.ezzat@utoronto.ca

    Affiliations: Ontario Cancer Institute, University Health Network, Toronto, Canada, The Endocrine Oncology Site Group, Princess Margaret Hospital, Toronto, Canada, Department of Medicine, University of Toronto, Toronto, Canada

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.pgen.1002400

About the Authors

Toru Tateno, Sylvia L. Asa, Lei Zheng, Shereen Ezzat
Ontario Cancer Institute, University Health Network, Toronto, Canada
Toru Tateno, Sylvia L. Asa, Lei Zheng, Shereen Ezzat
The Endocrine Oncology Site Group, Princess Margaret Hospital, Toronto, Canada
Toru Tateno, Lei Zheng, Shereen Ezzat
Department of Medicine, University of Toronto, Toronto, Canada
Sylvia L. Asa
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Thomas Mayr, Axel Ullrich
Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany

Corresponding Author

Email: shereen.ezzat@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SE SLA. Performed the experiments: TT LZ TM. Analyzed the data: TT SLA LZ SE. Contributed reagents/materials/analysis tools: TM AU. Wrote the paper: TT SLA SE.