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Research Article

Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types

  • Michael J. Ziller equal contributor,

    equal contributor Contributed equally to this work with: Michael J. Ziller, Fabian Müller

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America

    X
  • Fabian Müller equal contributor,

    equal contributor Contributed equally to this work with: Michael J. Ziller, Fabian Müller

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Max Planck Institute for Informatics, Saarbrücken, Germany

    X
  • Jing Liao,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America

    X
  • Yingying Zhang,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America

    X
  • Hongcang Gu,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Christoph Bock,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Max Planck Institute for Informatics, Saarbrücken, Germany

    X
  • Patrick Boyle,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Charles B. Epstein,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Bradley E. Bernstein,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Thomas Lengauer,

    Affiliation: Max Planck Institute for Informatics, Saarbrücken, Germany

    X
  • Andreas Gnirke,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Alexander Meissner mail

    alexander_meissner@harvard.edu

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America

    X
  • Published: December 08, 2011
  • DOI: 10.1371/journal.pgen.1002389

About the Authors

Michael J. Ziller, Fabian Müller, Jing Liao, Yingying Zhang, Hongcang Gu, Christoph Bock, Patrick Boyle, Charles B. Epstein, Bradley E. Bernstein, Andreas Gnirke, Alexander Meissner
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Michael J. Ziller, Fabian Müller, Jing Liao, Yingying Zhang, Christoph Bock, Alexander Meissner
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
Michael J. Ziller, Fabian Müller, Jing Liao, Yingying Zhang, Christoph Bock, Alexander Meissner
Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America
Fabian Müller, Christoph Bock, Thomas Lengauer
Max Planck Institute for Informatics, Saarbrücken, Germany
Bradley E. Bernstein
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
Bradley E. Bernstein
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Bradley E. Bernstein
Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: alexander_meissner@harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJZ AM. Performed the experiments: JL YZ HG PB. Analyzed the data: MJZ FM. Contributed reagents/materials/analysis tools: CB AG TL CBE BEB. Wrote the paper: MJZ FM AM.