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Research Article

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

  • Michael Blatzer equal contributor,

    equal contributor Contributed equally to this work with: Michael Blatzer, Bridget M. Barker

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Bridget M. Barker equal contributor,

    equal contributor Contributed equally to this work with: Michael Blatzer, Bridget M. Barker

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Sven D. Willger,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Nicola Beckmann,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Sara J. Blosser,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Elizabeth J. Cornish,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Aurelien Mazurie,

    Affiliation: Bioinformatics Core and Department of Microbiology, Montana State University, Bozeman, Montana, United States of America

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  • Nora Grahl,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Hubertus Haas mail,

    hubertus.haas@i-med.ac.at (HH); rcramer@montana.edu (RAC)

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

    These authors also contributed equally to this work.

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  • Robert A. Cramer mail

    hubertus.haas@i-med.ac.at (HH); rcramer@montana.edu (RAC)

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Published: December 01, 2011
  • DOI: 10.1371/journal.pgen.1002374

About the Authors

Michael Blatzer, Nicola Beckmann, Hubertus Haas
Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria
Bridget M. Barker, Sven D. Willger, Sara J. Blosser, Elizabeth J. Cornish, Nora Grahl, Robert A. Cramer
Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America
Aurelien Mazurie
Bioinformatics Core and Department of Microbiology, Montana State University, Bozeman, Montana, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HH RAC. Performed the experiments: MB BMB SDW NB SJB EJC AM NG HH RAC. Analyzed the data: MB BMB SDW NB SJB EJC AM NG HH RAC. Contributed reagents/materials/analysis tools: AM. Wrote the paper: MB BMB HH RAC.