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Research Article

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

  • Atsushi Kaneda mail,

    kaneda@genome.rcast.u-tokyo.ac.jp

    Affiliations: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, PRESTO, Japan Science and Technology Agency (JST), Tokyo, Japan

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  • Takanori Fujita,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Motonobu Anai,

    Affiliation: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Shogo Yamamoto,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Genta Nagae,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Masato Morikawa,

    Affiliation: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Shingo Tsuji,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Masanobu Oshima,

    Affiliation: Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

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  • Kohei Miyazono,

    Affiliation: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Hiroyuki Aburatani

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Published: November 03, 2011
  • DOI: 10.1371/journal.pgen.1002359

About the Authors

Atsushi Kaneda, Takanori Fujita, Shogo Yamamoto, Genta Nagae, Shingo Tsuji, Hiroyuki Aburatani
Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Atsushi Kaneda
PRESTO, Japan Science and Technology Agency (JST), Tokyo, Japan
Motonobu Anai
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Masato Morikawa, Kohei Miyazono
Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Masanobu Oshima
Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

Corresponding Author

Email: kaneda@genome.rcast.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AK MO KM HA. Performed the experiments: AK MA GN MM. Analyzed the data: AK TF SY ST. Contributed reagents/materials/analysis tools: MO KM HA. Wrote the paper: AK KM HA.