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Research Article

A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened

  • Seongjin Seo,

    Affiliations: Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    Current address: Department of Ophthalmology and Visual Sciences, University of Iowa College of Medicine, Iowa City, Iowa, United States of America

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  • Qihong Zhang,

    Affiliations: Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Kevin Bugge,

    Affiliations: Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • David K. Breslow,

    Affiliation: Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Charles C. Searby,

    Affiliations: Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Maxence V. Nachury,

    Affiliation: Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Val C. Sheffield mail

    val-sheffield@uiowa.edu

    Affiliations: Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Published: November 03, 2011
  • DOI: 10.1371/journal.pgen.1002358

About the Authors

Seongjin Seo, Qihong Zhang, Kevin Bugge, Charles C. Searby, Val C. Sheffield
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America
Seongjin Seo, Qihong Zhang, Kevin Bugge, Charles C. Searby, Val C. Sheffield
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
David K. Breslow, Maxence V. Nachury
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: val-sheffield@uiowa.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS MVN VCS. Performed the experiments: SS QZ KB DKB CCS. Analyzed the data: SS MVN VCS. Wrote the paper: SS VCS.