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Research Article

Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans

  • Calvin A. Mok,

    Affiliations: The Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

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  • Michael P. Healey,

    Affiliation: Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada

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  • Tanvi Shekhar,

    Affiliation: The Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

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  • Michel R. Leroux,

    Affiliation: Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada

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  • Elise Héon mail,

    zhen@lunenfeld.ca (MZ); elise.heon@sickkids.ca (HZ)

    Affiliations: The Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

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  • Mei Zhen mail

    zhen@lunenfeld.ca (MZ); elise.heon@sickkids.ca (HZ)

    Affiliations: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Published: October 13, 2011
  • DOI: 10.1371/journal.pgen.1002335

About the Authors

Calvin A. Mok, Tanvi Shekhar, Elise Héon
The Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
Calvin A. Mok, Mei Zhen
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Calvin A. Mok, Elise Héon, Mei Zhen
Institute of Medical Science, University of Toronto, Toronto, Canada
Michael P. Healey, Michel R. Leroux
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada
Mei Zhen
Department of Molecular Genetics, University of Toronto, Toronto, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAM EH MZ. Performed the experiments: CAM MPH TS MZ. Analyzed the data: CAM MPH TS MZ. Contributed reagents/materials/analysis tools: CAM MPH TS MRL EH MZ. Wrote the paper: CAM EH MZ.