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Research Article

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors

  • Lee E. Moore mail,

    moorele@mail.nih.gov

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Michael L. Nickerson,

    Affiliation: Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland, United States of America

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  • Paul Brennan,

    Affiliation: International Agency for Research on Cancer, Lyon, France

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  • Jorge R. Toro,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Erich Jaeger,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

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  • Jessica Rinsky,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Summer S. Han,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • David Zaridze,

    Affiliation: Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russia

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  • Vsevolod Matveev,

    Affiliation: Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russia

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  • Vladimir Janout,

    Affiliation: Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

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  • Hellena Kollarova,

    Affiliation: Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

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  • Vladimir Bencko,

    Affiliation: Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic

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  • Marie Navratilova,

    Affiliation: Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic

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  • Neonilia Szeszenia-Dabrowska,

    Affiliation: Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland

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  • Dana Mates,

    Affiliation: Institute of Public Health, Bucharest, Romania

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  • Laura S. Schmidt,

    Affiliations: Basic Science Program, SAIC–Frederick, NCI–Frederick, Frederick, Maryland, United States of America, Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Petra Lenz,

    Affiliation: Support to the Division of Cancer Epidemiology and Genetics, National Cancer Institute, SAIC-Frederick, NCI- Frederick, Frederick, Maryland, United States of America

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  • Sara Karami,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • W. Marston Linehan,

    Affiliation: Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Maria Merino,

    Affiliation: Support to the Division of Cancer Epidemiology and Genetics, National Cancer Institute, SAIC-Frederick, NCI- Frederick, Frederick, Maryland, United States of America

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  • Stephen Chanock,

    Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

    X
  • Paolo Boffetta,

    Affiliations: Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland, United States of America, The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York, United States of America, International Cancer Prevention Research Institute, Lyon, France

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  • Wong-Ho Chow,

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Frederic M. Waldman,

    Affiliation: University of California San Francisco, San Francisco, California, United States of America

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  • Nathaniel Rothman

    Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: October 13, 2011
  • DOI: 10.1371/journal.pgen.1002312

About the Authors

Lee E. Moore, Jorge R. Toro, Jessica Rinsky, Summer S. Han, Sara Karami, Stephen Chanock, Wong-Ho Chow, Nathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Michael L. Nickerson, Paolo Boffetta
Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland, United States of America
Paul Brennan
International Agency for Research on Cancer, Lyon, France
Erich Jaeger, Frederic M. Waldman
University of California San Francisco, San Francisco, California, United States of America
David Zaridze, Vsevolod Matveev
Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russia
Vladimir Janout, Hellena Kollarova
Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
Vladimir Bencko
Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic
Marie Navratilova
Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Neonilia Szeszenia-Dabrowska
Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland
Dana Mates
Institute of Public Health, Bucharest, Romania
Laura S. Schmidt
Basic Science Program, SAIC–Frederick, NCI–Frederick, Frederick, Maryland, United States of America
Laura S. Schmidt, W. Marston Linehan
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Petra Lenz, Maria Merino
Support to the Division of Cancer Epidemiology and Genetics, National Cancer Institute, SAIC-Frederick, NCI- Frederick, Frederick, Maryland, United States of America
Stephen Chanock
Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
Paolo Boffetta
The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York, United States of America
Paolo Boffetta
International Cancer Prevention Research Institute, Lyon, France

Corresponding Author

Email: moorele@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LE Moore, ML Nickerson, P Brennan, JR Toro, D Zaridze, V Janout, H Kollarova, V Bencko, M Navratilova, N Szeszenia-Dabrowska, D Mates, P Boffetta, W-H Chow, N Rothman. Performed the experiments: ML Nickerson, JR Toro, E Jaeger, V Matveev, P Lenz, LS Schmidt, WM Linehan, M Merino, S Chanock, FM Waldman. Analyzed the data: LE Moore, E Jaeger, J Rinsky, SS Han, P Lenz, S Karami. Contributed reagents/materials/analysis tools: LE Moore, ML Nickerson, P Brennan, JR Toro, LS Schmidt, WM Linehan, M Merino, S Chanock, P Boffetta, FM Waldman. Wrote the paper: LE Moore, ML Nickerson, P Brennan, JR Toro, J Rinsky, LS Schmidt, S Karami, WM Linehan, P Boffetta, W-H Chow, N Rothman.